Jia Liyuan, Zhang Jing, Ma Tianran, Guo Yayuan, Yu Yuan, Cui Jihong
Laboratory of Tissue Engineering, College of Life Sciences, Northwest University, Xi'an, China.
Laboratory for Functional Glycomics, College of Life Sciences, Northwest University, Xi'an, China.
Front Oncol. 2018 Dec 7;8:565. doi: 10.3389/fonc.2018.00565. eCollection 2018.
Lung cancer is a disease that influences human health and has become a leading cause of cancer mortality worldwide. However, it is frequently diagnosed at the advanced stage. It is necessary by means of biology to identify specific lung tumor biomarkers with high sensitivity. Glycosylation is one of the most important post-translational modifications and is related to many different diseases. It is involved in numerous essential biological processes, such as cell proliferation, differentiation, migration, cell-cell integrity and recognition, and immune modulation. However, little was known about deregulation of glycosylation in lung cancer and contribution to tumor-microenvironment interactions. Among the numerous glycosylations, fucosylation is the most common modification of glycoproteins and glycosylated oligosaccharides. Increased levels of fucosylation have been detected in various pathological conditions, as well as in lung cancer. In this article, we reviewed the role of fucosylation in lung cancer. We highlighted some of the fucosylation alterations currently being pursued in sera or tissues of lung cancer patients. Moreover, we elaborated on the regulation mechanism of fucosylation in proliferative invasion and metastasis of lung tumor cells. In summary, alterations in fucosylation provide potential biomarkers and therapeutic targets in lung cancer.
肺癌是一种影响人类健康的疾病，已成为全球癌症死亡的主要原因。然而，它常常在晚期才被诊断出来。通过生物学手段识别具有高灵敏度的特定肺肿瘤生物标志物很有必要。糖基化是最重要的翻译后修饰之一，与许多不同疾病相关。它参与众多重要的生物学过程，如细胞增殖、分化、迁移、细胞间完整性和识别以及免疫调节。然而，关于肺癌中糖基化失调及其对肿瘤微环境相互作用的贡献知之甚少。在众多糖基化中，岩藻糖基化是糖蛋白和糖基化寡糖最常见的修饰。在各种病理状况以及肺癌中都检测到岩藻糖基化水平升高。在本文中，我们综述了岩藻糖基化在肺癌中的作用。我们强调了目前在肺癌患者血清或组织中所研究的一些岩藻糖基化改变。此外，我们阐述了岩藻糖基化在肺肿瘤细胞增殖、侵袭和转移中的调控机制。总之，岩藻糖基化改变为肺癌提供了潜在的生物标志物和治疗靶点。
