Hetzel P, Gee T S
Am J Med. 1978 May;64(5):765-72. doi: 10.1016/0002-9343(78)90515-6.
Erythroleukemia is a disease manifested by an abnormal proliferation of erythroid and myeloid precursors, generally consisting of a primary erythroid phase (chronic erythemic myelosis), a transition phase involving erythroid and myeloid precursors (erythroleukemia) and, finally, the purely myeloblastic (acute myeloblastic leukemia) phase. The experience at Memorial Sloan-Kettering Cancer Center is reported. Presenting signs and symptoms are consistent with prior reports. The chemotherapy results in the past have been poor; because of the poor results, chemotherapy is started only if one of the following criteria are present: (1) frequent transfusion requirements; (2) rapidly increasing peripheral white blood cell count or percentage of leukemic blast forms; (3) frequent recurrent infectious and/or hemorrhagic complications. A hitherto unrecognized association of erythroleukemia and symptomatic rheumatic disease and numerous immunologic abberations are reported. The symptoms related to this rheumatic disorder do not seem to be relieved by therapy directed at the leukemic process, but rather by the use of simple anti-inflammatory agents.
红白血病是一种以红系和髓系前体细胞异常增殖为特征的疾病，通常包括一个原发性红系阶段（慢性血性骨髓增生症）、一个涉及红系和髓系前体细胞的过渡阶段（红白血病），以及最后纯粹的髓母细胞阶段（急性髓母细胞白血病）。本文报道了纪念斯隆-凯特琳癌症中心的经验。呈现的体征和症状与既往报道一致。过去化疗效果不佳；由于效果欠佳，仅在出现以下标准之一时才开始化疗：（1）频繁输血需求；（2）外周血白细胞计数或白血病原始细胞百分比迅速增加；（3）频繁复发的感染和/或出血并发症。本文报道了红白血病与症状性风湿性疾病以及众多免疫异常之间一种此前未被认识到的关联。与这种风湿性疾病相关的症状似乎不会因针对白血病病程的治疗而缓解，而是通过使用简单的抗炎药物得以缓解。
