Dauby Nicolas, Adler Catherine, Miendje Deyi Veronique Y, Sacheli Rosalie, Busson Laurent, Chamekh Mustapha, Marchant Arnaud, Barlow Patricia, De Wit Stéphane, Levy Jack, Melin Pierrette, Goetghebuer Tessa
Department of Infectious Diseases, Centre Hospitalier Universitaire Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Institute for Medical Immunology, Université Libre de Bruxelles (ULB), Gosselies, Belgium.
Open Forum Infect Dis. 2018 Nov 30;5(12):ofy320. doi: 10.1093/ofid/ofy320. eCollection 2018 Dec.
Group B streptococcus (GBS) infection is a leading cause of severe neonatal infection. Maternal GBS carriage during pregnancy is the main risk factor for both early-onset and late-onset GBS disease. High incidence of GBS infection has been reported in HIV-exposed but -uninfected infants (HEU). We aimed to determine the prevalence, characteristics, and risk factors for GBS colonization in HIV-infected and HIV-uninfected pregnant women living in Belgium.
Between January 1, 2011, and December 31, 2013, HIV-infected (n = 125) and -uninfected (n = 120) pregnant women had recto-vaginal swabs at 35-37 weeks of gestation and at delivery for GBS detection. Demographic, obstetrical, and HIV infection-related data were prospectively collected. GBS capsular serotyping was performed on a limited number of samples (33 from HIV-infected and 16 from HIV-uninfected pregnant women).
There was no significant difference in the GBS colonization rate between HIV-infected and -uninfected pregnant women (29.6% vs 24.2%, respectively). HIV-infected women were more frequently colonized by serotype III (36.4% vs 12.5%), and the majority of serotype III strains belonged to the hypervirulent clone ST-17. Exclusively trivalent vaccine serotypes (Ia, Ib, and III) were found in 57.6% and 75% of HIV-infected and -uninfected women, respectively, whereas the hexavalent vaccine serotypes (Ia, Ib, II, III, IV, and V) were found in 97% and 100%, respectively.
HIV-infected and -uninfected pregnant women living in Belgium have a similar GBS colonization rate. A trend to a higher colonization rate with serotype III was found in HIV-infected women, and those serotype III strains belong predominantly to the hypervirulent clone ST17.
B族链球菌（GBS）感染是严重新生儿感染的主要原因。孕期母亲携带GBS是早发型和晚发型GBS疾病的主要危险因素。据报道，暴露于HIV但未感染的婴儿（HEU）中GBS感染的发生率很高。我们旨在确定比利时感染HIV和未感染HIV的孕妇中GBS定植的患病率、特征和危险因素。
在2011年1月1日至2013年12月31日期间，感染HIV（n = 125）和未感染HIV（n = 120）的孕妇在妊娠35 - 37周时以及分娩时进行直肠阴道拭子检查以检测GBS。前瞻性收集人口统计学、产科和HIV感染相关数据。对有限数量的样本（33份来自感染HIV的孕妇，16份来自未感染HIV的孕妇）进行GBS荚膜血清分型。
感染HIV和未感染HIV的孕妇之间GBS定植率无显著差异（分别为29.6%和24.2%）。感染HIV的女性中血清型III的定植更为频繁（36.4%对12.5%），并且大多数血清型III菌株属于高毒力克隆ST - 17。分别在57.6%和75%的感染HIV和未感染HIV的女性中发现了仅三价疫苗血清型（Ia、Ib和III），而六价疫苗血清型（Ia、Ib、II、III、IV和V）分别在97%和100%的女性中被发现。
生活在比利时的感染HIV和未感染HIV的孕妇GBS定植率相似。在感染HIV的女性中发现血清型III的定植率有升高趋势，并且那些血清型III菌株主要属于高毒力克隆ST17。
