Kelley K W
University of Illinois, Urbana.
J Anim Sci. 1988 Aug;66(8):2095-108. doi: 10.2527/jas1988.6682095x.
Significant advances have been made in the field of immunophysiology since Selye discovered that acute stressors reduce the size of lymphoid organs. It is known that a variety of hormones other than glucocorticoids affect functional activities of lymphoid cells and macrophages. This paper summarizes recent findings of the effects of glucocorticoids and other hormones on lymphoid cells of domestic animals. Glucocorticoid and beta-adrenergic receptors are up-regulated on activated lymphoid cells. Classic pituitary hormones are synthesized by lymphoid cells, and both growth hormone and prolactin appear to have distinct roles as immunomodulators. In addition, certain activities of lymphoid cells may be behaviorally conditioned. These findings support the hypothesis that changes in the endocrine system affect lymphoid cells. They also suggest that products of the immune system affect the endocrine system. These findings provide a firm functional basis for the possibility of cross-talk between these two physiological systems.
自从塞利发现急性应激源会减小淋巴器官的大小以来，免疫生理学领域已经取得了重大进展。众所周知，除了糖皮质激素之外，多种激素也会影响淋巴细胞和巨噬细胞的功能活动。本文总结了糖皮质激素和其他激素对家畜淋巴细胞作用的近期研究结果。糖皮质激素和β-肾上腺素能受体在活化的淋巴细胞上上调。经典的垂体激素由淋巴细胞合成，生长激素和催乳素似乎都作为免疫调节剂发挥着独特作用。此外，淋巴细胞的某些活动可能受到行为调节。这些发现支持了内分泌系统的变化会影响淋巴细胞的假说。它们还表明免疫系统的产物会影响内分泌系统。这些发现为这两个生理系统之间相互作用的可能性提供了坚实的功能基础。
