State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering , Hunan University , Changsha 410082 , PR China.
School of Chemistry and Chemical Engineering , Hunan University of Science and Technology , Xiangtan , Hunan 411201 , China.
ACS Appl Mater Interfaces. 2019 Jan 30;11(4):3800-3808. doi: 10.1021/acsami.8b21299. Epub 2019 Jan 18.
Development of a facile but high-efficient small organic molecule-based photothermal therapy (PTT) in the in vivo transparent window (800-900 nm) has been regarded as a minimally invasive and most promising strategy for potential clinical cancer treatment. Phthalocyanine (Pc) molecules with remarkable photophysical and photochemical properties as well as high extinction coefficients in the near-infrared region are highly desirable for PTT, but as far satisfying single-component Pc-based PTT within the in vivo transparent window (800-900 nm) has very rarely been reported. Herein, inspired by the self-assembly algorithm of natural bacteriochlorophylls c, d, and e, biomimetic self-assembling tetrahexanoyl Pc Bio-ZnPc with outstanding light-harvesting capacity was demonstrated to exhibit excellent PTT efficacy evidenced by both in vitro and in vivo results, within the biological transparent window.
在体内透明窗口（800-900nm）内开发简便但高效的基于小分子的光热治疗（PTT）已被视为一种用于潜在临床癌症治疗的微创且最有前途的策略。酞菁（Pc）分子具有显著的光物理和光化学性质以及在近红外区域的高消光系数，非常适合 PTT，但在体内透明窗口（800-900nm）内满足单一成分 Pc 基 PTT 的情况极为罕见。受天然细菌叶绿素 c、d 和 e 的自组装算法的启发，仿生自组装四己酰基酞菁 Bio-ZnPc 具有出色的光捕获能力，在生物透明窗口内表现出优异的 PTT 效果，这一点从体外和体内实验结果都得到了证实。
