Feng Xing, Xiong Xiaoling, Ma Shenglin
Department of Thoracic Surgery, The Affiliated Hangzhou Hospital of Nanjing Medical University, Hangzhou, China.
Department of Thoracic Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Front Pharmacol. 2022 Mar 2;13:832725. doi: 10.3389/fphar.2022.832725. eCollection 2022.
Nowadays, non-small cell lung cancer (NSCLC) is threatening the health of all mankind. Although many progresses on treatment of lung cancer have been achieved in the past few decades, the current treatment methods are still traditional surgery, radiotherapy, and chemotherapy, which had poor selectivity and side effects. Lower-toxicity and more efficient treatments are in sore need. In this paper, a smart nanodelivery platform based on photothermal therapy, chemotherapy, and immunotherapy was constructed. The nanoparticles are composed of novel photothermal agents, Mn-modified phthalocyanine derivative (MnPC), docetaxel (DTX), and an effective targeting molecule, hyaluronic acid. The nanoplatform could release Mn from MnPC@DTX@PLGA@Mn@HA(MDPMH) and probably activate tumor immunity through cGAS-STING and chemotherapy, respectively. Furthermore, DTX could be released in the process for removal of tumor cells. The "one-for-all" nanomaterial may shed some light on treating NSCLC in multiple methods.
如今，非小细胞肺癌（NSCLC）正威胁着全人类的健康。尽管在过去几十年里肺癌治疗取得了许多进展，但目前的治疗方法仍然是传统的手术、放疗和化疗，这些方法选择性差且有副作用。急需毒性更低、更有效的治疗方法。本文构建了一种基于光热疗法、化疗和免疫疗法的智能纳米递送平台。纳米颗粒由新型光热剂、锰修饰的酞菁衍生物（MnPC）、多西他赛（DTX）和一种有效的靶向分子透明质酸组成。该纳米平台可以从MnPC@DTX@PLGA@Mn@HA（MDPMH）中释放锰，并可能分别通过cGAS-STING和化疗激活肿瘤免疫。此外，DTX可以在清除肿瘤细胞的过程中释放。这种“一药多用”的纳米材料可能为多种方法治疗NSCLC提供一些思路。
