Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Brazil.
Department of Neurology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Brazil.
Clin Exp Rheumatol. 2019 Jul-Aug;37(4):656-662. Epub 2018 Dec 20.
To assess serum interleukin (IL)-17A levels in patients with dermatomyositis (DM) and polymyositis (PM) and correlate them with the demographic, clinical, laboratory and therapeutic data of these diseases.
This was a cross-sectional, single-centre study that included defined DM and PM patients who were age-, gender- and ethnicity-matched to healthy individuals. Serum IL-17A analysis, as well as analysis for other cytokines (IL-6, TNFα and IFNγ), was performed by multiplex immunoassay. The disease status parameters were based on the International Myositis Assessment and Clinical Studies Group (IMACS) set scores.
Eighty DM, 32 PM patients and 104 healthy individuals were enrolled. Mean age of patients with DM and PM was 46.0 and 47.7, respectively, with a predominance of women and white ethnicity in both groups. Overall, clinical, laboratory, therapeutic, and current disease status were similar among patients with DM and PM. Median serum IL-17A level was higher in patients with PM and DM than the control group (0.73 vs. 0.49 vs. 0.35 pg/mL, respectively; p<0.050) and higher in PM when compared to DM (p<0.001). In DM, serum IL-17A levels were associated with cumulative cutaneous lesions, IMACS parameters, and serum IL-6 and IFNγ levels. In PM, serum IL-17A levels correlated with patients' current age, IMACS parameters and serum TNFα and IFNγ levels.
Serum IL-17A levels are not only increased, but also associated with disease activity in patients with DM and PM. Our data strongly suggest that IL-17A may be a biomarker of disease activity for these systemic autoimmune myopathies.
评估皮肌炎（DM）和多发性肌炎（PM）患者的血清白介素（IL）-17A 水平，并将其与这些疾病的人口统计学、临床、实验室和治疗数据相关联。
这是一项横断面、单中心研究，纳入了年龄、性别和种族匹配的明确 DM 和 PM 患者以及健康对照者。通过多重免疫分析检测血清 IL-17A 以及其他细胞因子（IL-6、TNFα 和 IFNγ）的水平。疾病状态参数基于国际肌炎评估和临床研究组（IMACS）设定的评分。
共纳入 80 例 DM、32 例 PM 患者和 104 名健康对照者。DM 和 PM 患者的平均年龄分别为 46.0 岁和 47.7 岁，两组均以女性和白种人为主。总体而言，DM 和 PM 患者的临床、实验室、治疗和当前疾病状态相似。PM 和 DM 患者的血清 IL-17A 水平均高于对照组（分别为 0.73、0.49 和 0.35pg/ml，p<0.050），且 PM 高于 DM（p<0.001）。在 DM 中，血清 IL-17A 水平与累积皮肤病变、IMACS 参数以及血清 IL-6 和 IFNγ 水平相关。在 PM 中，血清 IL-17A 水平与患者当前年龄、IMACS 参数以及血清 TNFα 和 IFNγ 水平相关。
DM 和 PM 患者的血清 IL-17A 水平不仅升高，而且与疾病活动度相关。我们的数据强烈表明，IL-17A 可能是这些系统性自身免疫性肌病的疾病活动度的生物标志物。
