生活的隐秘魅力。
The Hidden Charm of Life.
作者信息
Porcar Manuel
机构信息
Institute for Integrative Systems Biology I2SysBio, Universitat de València-CSIC, 46980 Paterna, Spain.
Darwin Bioprospecting Excellence, SL., Parc Científic Universitat de València, 46980 Paterna, Spain.
出版信息
Life (Basel). 2019 Jan 7;9(1):5. doi: 10.3390/life9010005.
Synthetic biology is an engineering view on biotechnology, which has revolutionized genetic engineering. The field has seen a constant development of metaphors that tend to highlight the similarities of cells with machines. I argue here that living organisms, particularly bacterial cells, are not machine-like, engineerable entities, but, instead, factory-like complex systems shaped by evolution. A change of the comparative paradigm in synthetic biology from machines to factories, from hardware to software, and from informatics to economy is discussed.
合成生物学是对生物技术的一种工程学视角，它彻底改变了基因工程。该领域不断涌现出各种隐喻，这些隐喻往往强调细胞与机器的相似性。我在此认为，生物体，尤其是细菌细胞，并非像机器一样可被设计的实体，而是由进化塑造的类似工厂的复杂系统。本文讨论了合成生物学中比较范式从机器到工厂、从硬件到软件、从信息学到经济学的转变。
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