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[同种异体角膜移植供体选择中的病毒学考量]

[Virologic considerations in donor selection for allogeneic keratoplasty].

作者信息

Bialasiewicz A A, Naumann G O, Jahn G J

机构信息

Augenklinik mit Poliklinik, Universität Erlangen-Nürnberg.

出版信息

Klin Monbl Augenheilkd. 1988 Jun;192(6):634-6. doi: 10.1055/s-2008-1050196.

DOI:10.1055/s-2008-1050196
PMID:3062243
Abstract

Over a period of 14 months (from October 1985 to December 1986) 152 potential cornea donors were evaluated for human immunodeficiency virus (HIV) and hepatitis B surface (HBs) antigen. In three clinically normal donors (two deaths due to natural causes, one as a result of an automobile accident), HIV seroconversion was found by ELISA techniques in two cases and a positive Western Blot test in one. The two elderly patients had previously undergone multiple blood transfusions during major abdominal surgery in smaller community hospitals before blood donors were routinely tested for HIV; one 20-year-old patient was probably a homosexual, as in-depth interviews with his family doctor revealed. Hepatitis B serology was positive in four potential cornea donors. The authors conclude that interdisciplinary work-ups of potential cornea donors should include screening for infectious diseases.

摘要

在14个月的时间里(从1985年10月至1986年12月),对152名潜在的角膜供体进行了人类免疫缺陷病毒(HIV)和乙型肝炎表面(HBs)抗原检测。在三名临床检查正常的供体中(两名因自然原因死亡,一名死于车祸),通过酶联免疫吸附测定(ELISA)技术发现两例HIV血清学转换,一例蛋白免疫印迹试验呈阳性。这两名老年患者此前在较小的社区医院接受腹部大手术时曾多次输血,当时献血者尚未常规检测HIV;对一名20岁患者的家庭医生进行深入访谈后发现,他可能是同性恋者。四名潜在的角膜供体乙型肝炎血清学检测呈阳性。作者得出结论,对潜在角膜供体进行多学科检查应包括传染病筛查。

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