Armstrong S A, Gangam N, Chipman M L, Rootman D S
Department of Preventative Medicine, University of Toronto, Ontario, Canada.
Cornea. 1997 Sep;16(5):512-6.
To determine the prevalence of hepatitis B (HBV), hepatitis C (HCV), and human immunodeficiency virus (HIV) in the serum of cornea donors who had been previously screened by social and medical history by the Eye Bank of Canada, Ontario Division.
A retrospective examination of the donor records of the Eye Bank of Canada, Ontario Division, was conducted. A total of 3,228 records were examined covering the period from May 17, 1993 to May 31, 1996.
The prevalence of HBV was determined to be 0.25%, HCV, 0.93%; and HIV, 0.031%.
The data revealed that despite the use of medical and social history to prescreen, a small percentage of prescreened donors test serologically positive. A comparison of the prevalence of HBV, HCV, and HIV in the prescreened cornea donors to a similarly screened cohort of blood donors over a similar time period reveals a higher prevalence in all three diseases in the cohort of cornea donors. An examination of the demographic characteristics of the population as a whole versus the three groups with confirmed serology failed to show a significant difference between the seropositive and seronegative groups. This study confirms the value and necessity of serologic prescreening of cornea donors as is currently the standard of practice.
确定曾由加拿大安大略省眼库通过社会和病史进行过初步筛查的角膜捐献者血清中乙型肝炎病毒（HBV）、丙型肝炎病毒（HCV）和人类免疫缺陷病毒（HIV）的流行率。
对加拿大安大略省眼库的捐献者记录进行回顾性检查。共检查了3228份记录，涵盖1993年5月17日至1996年5月31日期间。
确定HBV流行率为0.25%，HCV为0.93%，HIV为0.031%。
数据显示，尽管使用了医学和社会病史进行初步筛查，但仍有一小部分经过初步筛查的捐献者血清学检测呈阳性。将初步筛查的角膜捐献者中HBV、HCV和HIV的流行率与在相似时间段内经过类似筛查的献血者队列进行比较，发现角膜捐献者队列中这三种疾病的流行率更高。对总体人群与血清学确诊的三组人群的人口统计学特征进行检查，未发现血清阳性组和血清阴性组之间存在显著差异。本研究证实了目前作为标准做法对角膜捐献者进行血清学初步筛查的价值和必要性。
