Merinopoulos Ioannis, Corballis Natasha, Eccleshall Simon C, Vassiliou Vassilios S
Department of Cardiology, Norfolk and Norwich University Hospital, Norwich NR4 7UY, United Kingdom.
Department of Cardiology, West Suffolk Hospital and University of East Anglia, Bury St Edmunds IP33 2QZ, United Kingdom.
World J Cardiol. 2018 Dec 26;10(12):250-253. doi: 10.4330/wjc.v10.i12.250.
Sudden arrhythmic cardiac death remains a significant, potentially reversible, cardiological challenge in terms of creating accurate risk prediction models. The current guidelines for implantable cardioverter defibrillator (ICD) therapy are mainly based on left ventricular ejection fraction despite its low sensitivity and specificity in predicting sudden cardiac death (SCD). Chronic total occlusions have been associated with increased mortality but further research is required to clarify if they should be incorporated in a risk model predicting SCD aiming to identify patients that would benefit from ICD therapy even with preserved ejection fraction.
在创建准确的风险预测模型方面，心律失常性心脏猝死仍然是一个重大的、潜在可逆转的心脏病学挑战。目前植入式心脏复律除颤器（ICD）治疗指南主要基于左心室射血分数，尽管其在预测心源性猝死（SCD）方面的敏感性和特异性较低。慢性完全闭塞与死亡率增加有关，但需要进一步研究以明确它们是否应纳入旨在识别即使射血分数保留也能从ICD治疗中获益的患者的SCD风险预测模型。
