Chyou Anthony C, Klein Barbara E K, Klein Ronald, Barr R Graham, Cotch Mary Frances, Praestgaard Amy, Wong Tien Y, Lima Joao, Bluemke David A, Kawut Steven
Division of Cardiology and the Department of Medicine, Weill Cornell Medical College, New York Presbyterian Hospital, New York City, NY, USA.
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Pulm Circ. 2018 Dec 3;9(1):2045894018819781. doi: 10.1177/2045894018819781. eCollection 2019 Jan-Mar.
Retinal vessel diameters have been associated with left ventricular morphology and function but their relationship with the right ventricle (RV) has not been studied. We hypothesized that wider retinal venules and narrower retinal arterioles are associated with RV morphology and function. RV end-diastolic mass (RVEDM), end-diastolic volume (RVEDV), end-systolic volume (RVESV), stroke volume (RVSV), and ejection fraction (RVEF) were assessed using cardiac magnetic resonance imaging (MRI) scans of 4204 participants without clinical cardiovascular disease at the baseline examination; retinal photography was obtained at the second examination. Mean diameters of retinal arterioles and venules were measured and summarized as central retinal vein and artery equivalents ("veins" and "arteries," respectively). After adjusting for covariates, wider veins were associated with greater RVEDM and RVEDV in women ( = 0.04 and = 0.02, respectively), whereas there was an inverse association with RVEDV in men ( = 0.02). In both sexes, narrower arteries were associated with lower RVEDM ( < 0.001 in women and = 0.002 in men) and smaller RVEDV ( < 0.001 in women and = 0.04 in men) in adjusted models. Narrower arteries were also associated with lower RVEF in men but this was of borderline significance after adjusting for the LVEF ( = 0.08). Wider retinal venular diameter was associated with sex-specific changes in RVEDM and RVEDV in adults without clinical cardiovascular disease. Narrower retinal arteriolar diameter was associated with significantly lower RVEDM and smaller RVEDV in both sexes.
视网膜血管直径已被证实与左心室形态和功能有关，但它们与右心室（RV）的关系尚未得到研究。我们假设较宽的视网膜小静脉和较窄的视网膜小动脉与右心室形态和功能有关。在基线检查时，对4204名无临床心血管疾病的参与者进行心脏磁共振成像（MRI）扫描，评估右心室舒张末期质量（RVEDM）、舒张末期容积（RVEDV）、收缩末期容积（RVESV）、每搏输出量（RVSV）和射血分数（RVEF）；在第二次检查时获取视网膜照片。测量视网膜小动脉和小静脉的平均直径，并汇总为视网膜中央静脉和动脉等效值（分别为“静脉”和“动脉”）。在调整协变量后，较宽的静脉与女性更大的RVEDM和RVEDV相关（分别为P = 0.04和P = 0.02），而在男性中与RVEDV呈负相关（P = 0.02）。在两性中，较窄的动脉与调整模型中较低的RVEDM相关（女性P < 0.001，男性P = 0.002）和较小的RVEDV相关（女性P < 0.001，男性P = 0.04）。较窄的动脉在男性中也与较低的RVEF相关，但在调整左心室射血分数后这具有临界显著性（P = 0.08）。在无临床心血管疾病的成年人中，较宽的视网膜小静脉直径与RVEDM和RVEDV的性别特异性变化相关。较窄的视网膜小动脉直径在两性中均与显著较低的RVEDM和较小的RVEDV相关。
