Department of Medical Statistics and Epidemiology, Guangzhou Key Laboratory of Environmental Pollution and Health Assessment, Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-Sen University, Guangzhou, 510080, China.
Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, 02215, USA.
Sci Rep. 2020 Sep 9;10(1):14797. doi: 10.1038/s41598-020-71385-0.
Abnormal retinal microvascular geometry has been associated with cardiac remodeling and heart failure. However, its relation to cardiac function, prior to clinical disease has not been explored. In this cross-sectional study, 50 participants (mean age 62.5 ± 11.7 years) without cardiovascular disease (CVD) were recruited from the Cardiac Ageing Study. Transthoracic echocardiography imaging was performed to measure cardiac function indices, and retinal imaging was used to measure retinal vascular caliber and retinal vascular geometric indices. Multiple linear regressions were applied to examine associations between indices of cardiac function and retinal microvasculature, adjusting for age, sex, body mass index, mean blood pressure and comorbidity (i.e. hypertension, diabetes and dyslipidemia). After adjusting for confounders, each unit decrease in peak systolic septal mitral annular velocity (Septal S') indicating poorer left function was associated with smaller retinal venular branching angle (β: - 2.69°; 95% CI - 4.92, - 0.46). Furthermore, each unit increase in peak velocity flow in late diastole by atrial contraction (MV A Peak) indicating poorer left atrial function was associated with lower retinal venular fractal dimension (- 0.13Df; - 0.25, - 0.004). Our findings suggested a relationship between poorer cardiac function and suboptimal retinal microvascular geometry, among Chinese without CVD.
视网膜微血管形态异常与心脏重构和心力衰竭有关。然而，其与临床疾病发生前的心脏功能的关系尚未得到探索。在这项横断面研究中，我们从心脏衰老研究中招募了 50 名无心血管疾病（CVD）的参与者（平均年龄 62.5±11.7 岁）。通过经胸超声心动图成像来测量心脏功能指数，通过视网膜成像来测量视网膜血管口径和视网膜血管几何指数。应用多元线性回归来检验心脏功能和视网膜微血管之间的相关性，调整年龄、性别、体重指数、平均血压和合并症（即高血压、糖尿病和血脂异常）。在调整混杂因素后，每单位收缩期室间隔二尖瓣环速度峰值（Septal S'）的下降（提示左功能较差）与视网膜小静脉分支角度（β：-2.69°；95%CI -4.92，-0.46）减小相关。此外，每单位通过心房收缩的舒张晚期最大流速（MV A Peak）的增加（提示左心房功能较差）与视网膜小静脉分形维数降低相关（-0.13Df；-0.25，-0.004）。我们的研究结果表明，在中国无 CVD 的人群中，较差的心脏功能与视网膜微血管形态的不理想之间存在一定关系。
