Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Sweden.
Children's Clinic, Tartu University Hospital, Tartu, Estonia.
J Immunol Res. 2018 Nov 28;2018:3856897. doi: 10.1155/2018/3856897. eCollection 2018.
Liver-derived insulin-like growth factor-1 (IGF-1) contributes bone formation. Decreased IGF-1 levels are common in juvenile idiopathic arthritis (JIA), but whether IGF-1 is related to sex and differ during the pathogenic progress of JIA is unknown.
The aim of this study was to examine IGF-1 levels in boys and girls with newly diagnosed JIA, with established JIA and in controls.
The study group included 131 patients from the Estonian population-based prevalence JIA study. Blood samples were obtained from 27 boys and 38 girls with early JIA (≤1 month from the diagnosis), 29 boys and 36 girls with established JIA (mean disease duration 18 months), and from 47 age- and sex-matched controls.
IGF-1 levels in boys were significantly decreased in early JIA compared to male controls, while IGF-1 levels in girls were comparable between JIA and controls. In early JIA, IGF-1 levels were 12-fold lower in boys relative to girls. In controls, IGF-1 levels correlated with both age and height, while these correlations were lost in boys with early JIA.
We report a sex-dependent deficiency in serum IGF-1 in boys with early JIA, which argues for sex-related differences in biological mechanisms involved in the disease pathogenesis.
肝脏产生的胰岛素样生长因子-1（IGF-1）有助于骨骼形成。在青少年特发性关节炎（JIA）中，IGF-1 水平普遍降低，但 IGF-1 是否与性别有关，以及在 JIA 的发病过程中是否存在差异尚不清楚。
本研究旨在检测新诊断的 JIA 男孩和女孩、已确诊的 JIA 男孩和女孩以及对照组中 IGF-1 水平。
该研究纳入了来自爱沙尼亚基于人群的 JIA 患病率研究的 131 名患者。从 27 名早期 JIA（诊断后≤1 个月）男孩和 38 名女孩、29 名早期 JIA 男孩和 36 名女孩以及 47 名年龄和性别匹配的对照组中采集血样。
与男性对照组相比，早期 JIA 男孩的 IGF-1 水平显著降低，而 JIA 女孩的 IGF-1 水平与对照组相当。在早期 JIA 中，男孩的 IGF-1 水平相对女孩降低了 12 倍。在对照组中，IGF-1 水平与年龄和身高相关，但在早期 JIA 男孩中，这些相关性消失。
我们报告了早期 JIA 男孩血清 IGF-1 存在性别依赖性缺乏，这表明疾病发病机制中涉及的生物学机制存在性别相关差异。
