Centre for Bone and Arthritis Research at Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Department of Odontology, Division of Molecular Periodontology, Umeå University, Umeå, Sweden.
J Clin Periodontol. 2019 Jun;46 Suppl 21:33-51. doi: 10.1111/jcpe.13051.
In this article, the interplay between bone resorbing and bone forming cells is reviewed.
This review examines the comprehensive literature on the interaction between bone resorption and bone formation.
Coupling between bone resorption and bone formation refers to the process within basic multicellular units, in which osteoclastic bone resorption is met by the differentiation of osteoblasts and their bone forming activity. There are many possible signalling molecules that contribute to coupling at the asynchronously working remodelling sites throughout our skeleton. These include growth factors released from the bone matrix during bone resorption, soluble and membrane products of the osteoclasts and their precursors and signals from osteocytes.
In this review, we describe the potential roles of a number of these factors, whose interactions are essential for a tight control of coupling within individual remodelling units, in order to control skeletal mass. Both pre-clinical evidence and clinical evidence pinpoint that molecules in the WNT signalling pathway could be promising bone augmentation therapeutic targets. Regarding oral implications, there is support, from preclinical studies in rats, that anti-sclerostin antibodies can restore alveolar bone mass.
本文综述了破骨细胞和成骨细胞之间的相互作用。
本综述检查了关于骨吸收和骨形成相互作用的综合文献。
骨吸收和骨形成之间的偶联是指在基本多细胞单位内发生的过程，其中破骨细胞的骨吸收伴随着成骨细胞的分化及其成骨活性。在我们骨骼的所有改建部位，有许多可能的信号分子有助于偶联，这些信号分子包括骨吸收过程中从骨基质中释放的生长因子、破骨细胞及其前体细胞的可溶性和膜产物以及骨细胞的信号。
在这篇综述中，我们描述了其中一些因子的潜在作用，它们的相互作用对于单个改建单位内偶联的紧密控制至关重要，以控制骨骼质量。临床前证据和临床证据都指出，WNT 信号通路中的分子可能是有前途的骨增强治疗靶点。关于口腔方面的影响，有研究支持，抗硬骨素抗体可以恢复牙槽骨量。
