a Nutrition and Endocrine Research Center , Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences , Tehran , Iran.
b Endocrine Research Center , Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences , Tehran , Iran.
Biomarkers. 2019 Jun;24(4):325-333. doi: 10.1080/1354750X.2019.1567816. Epub 2019 Feb 15.
This study was conducted to investigate whether serum NO metabolites (NO) could predict the occurrence of type 2 diabetes (T2DM), hypertension (HTN) and metabolic syndrome (MetS). We measured serum NO concentrations in the Tehran Lipid and Glucose Study participants (aged ≥19 years) and followed them for a median of 7.7 years for the incidence of outcomes. To determine the appropriate cut-off points of serum NO for predicting clinical events, a random sampling method (50:50 ratio) was used for the population and for analysis, receiver operator characteristic curve was used. Multivariable Cox proportional hazard models were used to estimate the hazard ratios (HRs) with 95% confidence intervals (95% CIs) of T2DM, HTN and MetS in response to serum NO values. The optimal cut-off points of serum NO levels for predicting T2DM, HTN and MetS were 26.5, 25.5 and 25.5 µmol/L, respectively. Participants with serum NO levels ≥25.5 µmol/L had increased risk of MetS (HR = 1.31, 95% CI = 1.01-1.72). No evidence was found for any association of serum NO with incidence of T2DM and HTN (HR = 1.03, 95% CI = 0.83-1.77 and HR = 1.09, 95% CI = 0.88-1.35). In this prospective population-based investigation, a higher circulating NO was associated with development of MetS.
本研究旨在探讨血清一氧化氮代谢产物（NO）是否可预测 2 型糖尿病（T2DM）、高血压（HTN）和代谢综合征（MetS）的发生。我们测量了 Tehran Lipid and Glucose Study 参与者（年龄≥19 岁）的血清 NO 浓度，并对其进行了中位 7.7 年的随访，以观察结局的发生。为了确定血清 NO 预测临床事件的适当截断值，采用随机抽样法（50:50 比例）对人群和分析进行分组，同时采用受试者工作特征曲线进行分析。采用多变量 Cox 比例风险模型估计血清 NO 值与 T2DM、HTN 和 MetS 风险比（HR）及 95%置信区间（95%CI）。血清 NO 水平预测 T2DM、HTN 和 MetS 的最佳截断值分别为 26.5、25.5 和 25.5μmol/L。血清 NO 水平≥25.5μmol/L 的患者发生 MetS 的风险增加（HR=1.31，95%CI=1.01-1.72）。但没有证据表明血清 NO 与 T2DM 和 HTN 的发病风险有关（HR=1.03，95%CI=0.83-1.77 和 HR=1.09，95%CI=0.88-1.35）。在这项前瞻性的基于人群的研究中，较高的循环 NO 与 MetS 的发生有关。
