Kalnins Paul, Brucker Mikael, Spears Donald
Department of Naturopathic and Chinese Medicine, National University of Natural Medicine, Portland, OR.
National University of Natural Medicine, Portland, OR.
Perm J. 2019;23:18-074. doi: 10.7812/TPP/18-074.
Idiopathic pulmonary fibrosis (IPF) is a lethal, chronic, degenerative disease most commonly affecting the elderly population. The pathologic finding of this restrictive lung condition is excessive deposition of fibrotic tissue in the alveolar interstitium. Conventional therapies minimally alter the course of disease, and mean survival time from diagnosis is only 2 to 4 years.
A 65-year-old man, diagnosed with IPF in 2007, was being monitored by a conventional pulmonologist while being treated with weekly acupuncture targeting a Chinese medicine diagnosis of spleen dampness and lung qi weakness and with botanical medicine targeting the stimulation of adrenal dehydroepiandrosterone secretion. He survived for 10 years after diagnosis.
Studies exist linking dehydroepiandrosterone with IPF disease activity as well as acupuncture with antifibrotic activity. Larger clinical studies are needed to substantiate the link between acupuncture and/or dehydroepiandrosterone-stimulating herbs for the treatment of IPF.
特发性肺纤维化(IPF)是一种致命的慢性退行性疾病,最常影响老年人群。这种限制性肺病的病理表现是肺泡间质中纤维组织过度沉积。传统疗法对疾病进程的改变微乎其微,从诊断起的平均生存时间仅为2至4年。
一名65岁男性,于2007年被诊断为IPF,在接受常规肺科医生监测的同时,接受针对中医诊断的脾虚湿盛和肺气虚的每周一次针灸治疗,以及旨在刺激肾上腺脱氢表雄酮分泌的植物药治疗。他在诊断后存活了10年。
有研究将脱氢表雄酮与IPF疾病活动联系起来,也有研究将针灸与抗纤维化活动联系起来。需要更大规模的临床研究来证实针灸和/或刺激脱氢表雄酮分泌的草药与IPF治疗之间的联系。