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Acupuncture Treatment for Dyspnea due to Combined Pulmonary Fibrosis and Emphysema: A Case Report.
J Altern Complement Med. 2015 Dec;21(12):804-9. doi: 10.1089/acm.2015.0132. Epub 2015 Oct 23.
2
Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis.尼达尼布治疗特发性肺纤维化的疗效和安全性。
N Engl J Med. 2014 May 29;370(22):2071-82. doi: 10.1056/NEJMoa1402584. Epub 2014 May 18.
3
Acupuncture in treating hepatic fibrosis: a review with recommendation for future studies.针灸治疗肝纤维化:一项综述及对未来研究的建议
Afr J Tradit Complement Altern Med. 2012 Jul 1;9(4):452-8. doi: 10.4314/ajtcam.v9i4.1. eCollection 2012.
4
Dehydroepiandrosterone has strong antifibrotic effects and is decreased in idiopathic pulmonary fibrosis.去氢表雄酮具有很强的抗纤维化作用,在特发性肺纤维化中减少。
Eur Respir J. 2013 Nov;42(5):1309-21. doi: 10.1183/09031936.00027412. Epub 2012 Nov 8.
5
Acupuncture combined with curcumin attenuates carbon tetrachloride-induced hepatic fibrosis in rats.针刺联合姜黄素减轻大鼠四氯化碳诱导的肝纤维化。
Acupunct Med. 2012 Jun;30(2):132-8. doi: 10.1136/acupmed-2011-010116. Epub 2012 Feb 24.
6
An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management.特发性肺纤维化:诊断和管理的循证指南(美国胸科学会/欧洲呼吸学会/日本呼吸学会/拉丁美洲胸科学会联合发布)
Am J Respir Crit Care Med. 2011 Mar 15;183(6):788-824. doi: 10.1164/rccm.2009-040GL.
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Liquorice and glycyrrhetinic acid increase DHEA and deoxycorticosterone levels in vivo and in vitro by inhibiting adrenal SULT2A1 activity.甘草和甘草次酸通过抑制肾上腺 SULT2A1 活性,在体内和体外均可增加 DHEA 和脱氧皮质酮的水平。
Mol Cell Endocrinol. 2011 Apr 10;336(1-2):102-9. doi: 10.1016/j.mce.2010.12.011. Epub 2010 Dec 22.
8
Classification and natural history of the idiopathic interstitial pneumonias.特发性间质性肺炎的分类与自然史
Proc Am Thorac Soc. 2006 Jun;3(4):285-92. doi: 10.1513/pats.200601-005TK.
9
Nationwide prevalence of sporadic and familial idiopathic pulmonary fibrosis: evidence of founder effect among multiplex families in Finland.散发性和家族性特发性肺纤维化的全国患病率:芬兰多个家族中奠基者效应的证据。
Thorax. 2002 Apr;57(4):338-42. doi: 10.1136/thorax.57.4.338.

一名特发性肺纤维化患者在接受针灸、促脱氢表雄酮草药及传统治疗后生存期延长:病例报告

Prolonged Survival in a Patient with Idiopathic Pulmonary Fibrosis Receiving Acupuncture and DHEA-Promoting Herbs with Conventional Management: A Case Report.

作者信息

Kalnins Paul, Brucker Mikael, Spears Donald

机构信息

Department of Naturopathic and Chinese Medicine, National University of Natural Medicine, Portland, OR.

National University of Natural Medicine, Portland, OR.

出版信息

Perm J. 2019;23:18-074. doi: 10.7812/TPP/18-074.

DOI:10.7812/TPP/18-074
PMID:30624191
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6326563/
Abstract

INTRODUCTION

Idiopathic pulmonary fibrosis (IPF) is a lethal, chronic, degenerative disease most commonly affecting the elderly population. The pathologic finding of this restrictive lung condition is excessive deposition of fibrotic tissue in the alveolar interstitium. Conventional therapies minimally alter the course of disease, and mean survival time from diagnosis is only 2 to 4 years.

CASE PRESENTATION

A 65-year-old man, diagnosed with IPF in 2007, was being monitored by a conventional pulmonologist while being treated with weekly acupuncture targeting a Chinese medicine diagnosis of spleen dampness and lung qi weakness and with botanical medicine targeting the stimulation of adrenal dehydroepiandrosterone secretion. He survived for 10 years after diagnosis.

DISCUSSION

Studies exist linking dehydroepiandrosterone with IPF disease activity as well as acupuncture with antifibrotic activity. Larger clinical studies are needed to substantiate the link between acupuncture and/or dehydroepiandrosterone-stimulating herbs for the treatment of IPF.

摘要

引言

特发性肺纤维化(IPF)是一种致命的慢性退行性疾病,最常影响老年人群。这种限制性肺病的病理表现是肺泡间质中纤维组织过度沉积。传统疗法对疾病进程的改变微乎其微,从诊断起的平均生存时间仅为2至4年。

病例介绍

一名65岁男性,于2007年被诊断为IPF,在接受常规肺科医生监测的同时,接受针对中医诊断的脾虚湿盛和肺气虚的每周一次针灸治疗,以及旨在刺激肾上腺脱氢表雄酮分泌的植物药治疗。他在诊断后存活了10年。

讨论

有研究将脱氢表雄酮与IPF疾病活动联系起来,也有研究将针灸与抗纤维化活动联系起来。需要更大规模的临床研究来证实针灸和/或刺激脱氢表雄酮分泌的草药与IPF治疗之间的联系。