Cutler J E, Binder P S, Paul T O, Beamis J F
Arch Ophthalmol. 1978 Apr;96(4):689-91. doi: 10.1001/archopht.1978.03910050379016.
A severe granulomatous iridocyclitis developed in association with a cavitary pulmonary lesion in a 29-year-old man. The initial diagnosis and treatment was for pulmonary tuberculosis with tuberculous uveitis. Although the pulmonary lesion improved with antituberculous therapy, the condition of the eye deteriorated. An anterior-chamber tap was positive for Coccidioides immitis, and the patient was treated with intravenous and two intracameral injections of amphotericin B. The eye was ultimately enucleated three weeks after the initial intracameral injection, and yet was culture-positive for the organism. Histopathologic examination disclosed diffuse involvement of the anterior segment, with multiple spherules present within the iris and limbus.
一名29岁男性发生严重的肉芽肿性虹膜睫状体炎，并伴有肺部空洞性病变。最初诊断为肺结核合并结核性葡萄膜炎并进行相应治疗。尽管抗结核治疗使肺部病变有所改善，但眼部病情却恶化了。前房穿刺液检测出粗球孢子菌阳性，遂对该患者静脉注射两性霉素B，并进行了两次前房内注射。在首次前房内注射三周后，该眼最终被摘除，但仍培养出该病原体阳性。组织病理学检查显示前段弥漫性受累，虹膜和角膜缘内有多个球形体。
