Stone W S, Gold P E
Department of Psychology, University of Virginia, Charlottesville 22903.
Neurobiol Aging. 1988 Sep-Dec;9(5-6):719-27. doi: 10.1016/s0197-4580(88)80137-4.
Age-related changes in sleep are observed in many species, including rats and humans. Old rats often exhibit less total and paradoxical sleep, shorter sleep bouts and more random sleep-wake periods across 24 hours, than young rats. This paper evaluates recent evidence that deterioration of selected sleep parameters, usually involving levels of paradoxical sleep or durations of sleep bouts, may be related to deterioration of memory in old rats. Similar findings are reviewed with respect to young animals with different forms of experimentally-induced amnesia. Furthermore, a drug that enhances memory in rats and old humans, glucose, also enhances paradoxical sleep in old rats. These data suggest the utility of sleep measures as neurobiological markers of memory dysfunction in old rats.
在包括大鼠和人类在内的许多物种中都观察到了与年龄相关的睡眠变化。与年轻大鼠相比，老年大鼠通常在24小时内的总睡眠时间和异相睡眠时间更少，睡眠周期更短，睡眠-觉醒周期更随机。本文评估了最近的证据，即某些睡眠参数的恶化，通常涉及异相睡眠水平或睡眠周期时长，可能与老年大鼠的记忆衰退有关。对于患有不同形式实验性失忆症的年轻动物，也对类似的研究结果进行了综述。此外，一种能增强大鼠和老年人类记忆力的药物——葡萄糖，也能增强老年大鼠的异相睡眠。这些数据表明，睡眠指标可作为老年大鼠记忆功能障碍的神经生物学标志物。
