Stone W S, Wenk G L, Olton D S, Gold P E
Department of Psychology, University of Virginia.
J Gerontol. 1990 Sep;45(5):B169-73. doi: 10.1093/geronj/45.5.b169.
Poor glucose regulation predicts memory deficits in individual elderly humans. The present experiment determined whether glucose regulation was also related to memory and to sleep in aged rodents. Glucose regulation, inhibitory avoidance, and daytime sleep were assessed in young (3-month-old) and old (24-month-old) rats. Correlations were obtained between glucose regulation and the other variables in individual rats. In old rats, the magnitude of increases in blood glucose levels after glucose injections (500 mg/kg) was inversely correlated with retention of inhibitory avoidance and duration of paradoxical sleep bouts. In young rats, these measures were not significantly correlated. Because the deficits in sleep and memory in aged rats were largely confined to those rats with poor glucose control, peripheral glucose regulation may be a useful biological marker that accompanies cognitive and neurobiological dysfunction during aging.
血糖调节不佳预示着个体老年人类的记忆缺陷。本实验确定了血糖调节是否也与老年啮齿动物的记忆和睡眠有关。在年轻（3个月大）和年老（24个月大）的大鼠中评估了血糖调节、抑制性回避和白天睡眠情况。获得了个体大鼠血糖调节与其他变量之间的相关性。在老年大鼠中，注射葡萄糖（500mg/kg）后血糖水平升高的幅度与抑制性回避的保持和异相睡眠发作的持续时间呈负相关。在年轻大鼠中，这些指标没有显著相关性。由于老年大鼠的睡眠和记忆缺陷主要局限于血糖控制不佳的大鼠，外周血糖调节可能是衰老过程中伴随认知和神经生物学功能障碍的一个有用的生物学标志物。
