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[玫瑰花结形成淋巴细胞作为特发性血小板减少性紫癜的预后指标]

[Rosette forming lymphocytes as prognostic indices in idiopathic thrombocytopenic purpura].

作者信息

Martínez Cairo S, Farfán Canto J M, Alanís F, Gaitán Ramírez F

出版信息

Bol Med Hosp Infant Mex. 1978 Jul-Aug;35(4):585-90.

PMID:306255
Abstract

The study included 12 patients with acute ITP to whom subpopulations of rosette forming lymphocytes were determined in peripheral blood and in serial form, the number of platelets to establish a correlation as prognostic index in the evolution of the disease. No correlation was found between the progressive increment of platelets in the evolution of the disease. However, in patients with a tendency to remission, the percentage of E(T) rosette forming lymphocytes was low and normal that of EAC (B) lymphocytes. Dissimilarly, it was seen that in patients without tendency to remission, the percentage of T and B rosette forming lymphocytes was within normal limits. This seems to show that determination of the subpopulations of lymphocytes may be useful as a prognostic index in this stage of the disease.

摘要

该研究纳入了12例急性免疫性血小板减少性紫癜患者,对其外周血中形成玫瑰花结的淋巴细胞亚群进行了测定,并连续测定血小板数量,以建立一种关联作为疾病进展的预后指标。在疾病进展过程中,未发现血小板的逐渐增加之间存在相关性。然而,在有缓解倾向的患者中,E(T)形成玫瑰花结的淋巴细胞百分比低,而EAC(B)淋巴细胞百分比正常。相反,在无缓解倾向的患者中,T和B形成玫瑰花结的淋巴细胞百分比在正常范围内。这似乎表明,淋巴细胞亚群的测定在疾病的这一阶段可能作为一种预后指标有用。

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