Vargas Origel A, Contreras Méndez G, Domínguez Camacho C, Jasso Gutiérrez L, Chávez Hernández F
Bol Med Hosp Infant Mex. 1978 Jul-Aug;35(4):703-10.
The study included 50 newborns with (RDS) and 41 controls in relation with the plasma concentration of alpha-antitrypsin (a-l-AT) and of proteins. The blood samples were taken at 24, 72 and 120 postnatal hours. At 24 hours, in infants with IRDS 187.5 +/- 9 mg/dl of a-l-AT were shown and 4.15 +/- 0.09 g. % of total proteins, which compared with concentrations of a-l-AT and total proteins in controls of the same age, turned out significantly lower. The a-l-AT and total proteins suffered increment in their concentrations at 72 hours of life in relation to control cases in whom there was no modifications in the course of postnatal age. Among other factors, a drop in total protein was considered related to the drop in globulin fraction. The usefulness of quantification of a-l-AT for the diagnosis of IRDS, is pointed out at the end.
该研究纳入了50例患有呼吸窘迫综合征（RDS）的新生儿和41例对照，研究其α-抗胰蛋白酶（α-1-AT）和蛋白质的血浆浓度。在出生后24小时、72小时和120小时采集血样。在24小时时，患有特发性呼吸窘迫综合征（IRDS）的婴儿显示α-1-AT为187.5±9mg/dl，总蛋白为4.15±0.09g.%，与同年龄对照组的α-1-AT和总蛋白浓度相比，明显较低。与出生后年龄过程中无变化的对照病例相比，出生72小时时α-1-AT和总蛋白的浓度有所增加。在其他因素中，总蛋白下降被认为与球蛋白部分下降有关。最后指出了α-1-AT定量对IRDS诊断的有用性。
