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[磷脂酶在遭受过氧化的光感受器膜“修复”中的作用]

[Participation of phospholipases in the "repair" of photoreceptor membranes subjected to peroxidation].

作者信息

Kagan V E, Shvedova A A, Novikov K N

出版信息

Biofizika. 1978 Mar-Apr;23(2):279-84.

PMID:306262
Abstract

Results are presented showing that Ca++-activated endogenous phospholipases are able to catalyze hydrolysis of hydroperoxydiacyglycerophosphatides with subsequent formation of monoacyglycerophosphatides and free hydroperoxides of fatty acids in frog rod outer segment membranes. The role of endogenous phospholipases in the mechanisms of repair of photoreceptor membranes subjected to lipid peroxidation, as well as in "molecular substitution" of phospholipids under membrane renewal is discussed.

摘要

结果表明,钙离子激活的内源性磷脂酶能够催化蛙视杆细胞外段膜中氢过氧二酰基甘油磷脂的水解,随后形成单酰基甘油磷脂和游离脂肪酸氢过氧化物。本文讨论了内源性磷脂酶在遭受脂质过氧化的光感受器膜修复机制中的作用,以及在膜更新过程中磷脂的“分子替代”作用。

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