Kakiuchi Yosuke, Sakata Shinya, Nakamura Kazuyoshi, Okabayashi Hiroko, Akaike Kimitaka, Tokunaga Takayuki, Saeki Sho, Fujii Kazuhiko, Ichiyasu Hidenori
Department of Respiratory Medicine, Kumamoto University Hospital, Japan.
Department of Gastroenterology and Hepatology, Graduate School of Medical Science, Kumamoto University, Japan.
Intern Med. 2019 May 1;58(9):1329-1333. doi: 10.2169/internalmedicine.1446-18. Epub 2019 Jan 10.
A 76-year-old Japanese woman with recurrent hepatocellular carcinoma presented with acute exacerbation of idiopathic interstitial pneumonia (AE-IIP) after transcatheter arterial therapy using miriplatin. She had a history of preexisting IIP five years before presenting at our hospital. On day 4 after transcatheter arterial therapy, she complained of shortness of breath. Subsequently, she developed acute respiratory failure on day 11 after transcatheter arterial therapy. Chest computed tomography revealed extensive ground-glass opacity and traction bronchiectasis in bilateral lung fields; subsequently, she was diagnosed with AE-IIP triggered by transcatheter arterial therapy using miriplatin. Despite systemic administration of high-dose corticosteroid and cyclophosphamide, she died of respiratory failure on day 36.
一名76岁的日本女性，患有复发性肝细胞癌，在使用米铂进行经导管动脉治疗后出现特发性间质性肺炎急性加重（AE-IIP）。她在我院就诊前五年有特发性间质性肺炎病史。经导管动脉治疗后第4天，她主诉呼吸急促。随后，在经导管动脉治疗后第11天出现急性呼吸衰竭。胸部计算机断层扫描显示双侧肺野广泛磨玻璃影和牵拉性支气管扩张；随后，她被诊断为由使用米铂的经导管动脉治疗引发的AE-IIP。尽管全身给予大剂量皮质类固醇和环磷酰胺，她仍在第36天死于呼吸衰竭。
