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中枢阿片受体参与对中枢给予催产素诱导的抗伤害感受的调节。

Involvement of central opiate receptors in modulation of centrally administered oxytocin-induced antinociception.

作者信息

Erfanparast Amir, Tamaddonfard Esmaeal, Seyedin Sahar

机构信息

Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.

Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.

出版信息

Iran J Basic Med Sci. 2018 Dec;21(12):1275-1280. doi: 10.22038/ijbms.2018.26302.6449.

DOI:10.22038/ijbms.2018.26302.6449
PMID:30627372
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6312677/
Abstract

OBJECTIVES

Oxytocin is involved in modulation of many brain-mediated functions. In the present study, we investigated the central effects of oxytocin and its receptor antagonist, atosiban on inflammatory pain. The contribution of opiate receptors was explored using non-selective and selective antagonists.

MATERIALS AND METHODS

The fourth ventricle of the brain of anesthetized rats was implanted with a guide cannula. Inflammatory pain in the orofacial region was induced by subcutaneous (SC) injection of formalin into the vibrissa pad, and time duration of face rubbing behavior was measured for 45 min.

RESULTS

A typical biphasic pain was observed after formalin injection. This biphasic pain behavior was attenuated by intra-fourth ventricle administration of oxytocin (12.5, 50, and 200 ng/rat). Central prior administration of 400 ng/rat atosiban (an oxytocin receptor antagonist), naloxone (a non-selective opiate receptor antagonist), naloxonazine (a selective µ-opiate receptor antagonist), and nor-binaltorphimine (a selective κ-opiate receptor antagonist), but not naltrindole (a δ-opiate receptor antagonist), prevented oxytocin-induced (200 ng/rat) antinociception. Except for naltrindole, other antagonists increased pain intensity when used alone. Above-mentioned drugs did not alter locomotor activity.

CONCLUSION

Oxytocin, as a neuropeptide neurotransmitter, may be involved in the supraspinal modulation of inflammatory pain through µ- and κ-, but not δ-opiate receptors.

摘要

目的

催产素参与多种大脑介导功能的调节。在本研究中，我们研究了催产素及其受体拮抗剂阿托西班对炎性疼痛的中枢作用。使用非选择性和选择性拮抗剂探讨阿片受体的作用。

材料与方法

将麻醉大鼠脑的第四脑室植入引导套管。通过将福尔马林皮下注射到触须垫来诱导口面部区域的炎性疼痛，并测量揉脸行为的持续时间45分钟。

结果

福尔马林注射后观察到典型的双相疼痛。第四脑室内注射催产素（12.5、50和200 ng/只大鼠）可减轻这种双相疼痛行为。预先向中枢给予400 ng/只大鼠的阿托西班（一种催产素受体拮抗剂）、纳洛酮（一种非选择性阿片受体拮抗剂）、纳洛嗪（一种选择性μ-阿片受体拮抗剂）和去甲丙氧芬（一种选择性κ-阿片受体拮抗剂），但不包括纳曲吲哚（一种δ-阿片受体拮抗剂），可阻止催产素诱导（200 ng/只大鼠）的镇痛作用。除纳曲吲哚外，其他拮抗剂单独使用时会增加疼痛强度。上述药物不改变运动活性。

结论

催产素作为一种神经肽神经递质，可能通过μ-和κ-阿片受体而非δ-阿片受体参与炎性疼痛的脊髓上调制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ad2/6312677/ee9808b26752/IJBMS-21-1275-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ad2/6312677/7158aeba05a4/IJBMS-21-1275-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ad2/6312677/7fdd6878be08/IJBMS-21-1275-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ad2/6312677/a0425e3de8e4/IJBMS-21-1275-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ad2/6312677/9d8d72362a25/IJBMS-21-1275-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ad2/6312677/d2506ee1a633/IJBMS-21-1275-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ad2/6312677/a4d960f2d565/IJBMS-21-1275-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ad2/6312677/0cf2b9615b4e/IJBMS-21-1275-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ad2/6312677/ee9808b26752/IJBMS-21-1275-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ad2/6312677/7158aeba05a4/IJBMS-21-1275-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ad2/6312677/7fdd6878be08/IJBMS-21-1275-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ad2/6312677/a0425e3de8e4/IJBMS-21-1275-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ad2/6312677/9d8d72362a25/IJBMS-21-1275-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ad2/6312677/d2506ee1a633/IJBMS-21-1275-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ad2/6312677/a4d960f2d565/IJBMS-21-1275-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ad2/6312677/0cf2b9615b4e/IJBMS-21-1275-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ad2/6312677/ee9808b26752/IJBMS-21-1275-g008.jpg

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