Sánchez Jorge, Sánchez Andres, Sánchez Jorge
Group of Clinical and Experimental Allergology, IPS University, University of Antioquia, Medellín, Colombia.
Foundation for the Development of Medical and Biological Sciences, Cartagena, Colombia.
Allergy Rhinol (Providence). 2018 Dec 17;9:2152656718815870. doi: 10.1177/2152656718815870. eCollection 2018 Jan-Dec.
Epidemiological and experimental studies suggest that air pollution has a negative impact on human health and modifies the environment. However, the clinical implications of changes in environmental allergens secondary to air pollution have been little studied.
To explore if the growth conditions of the (rural vs urban area) modify the inflammatory response among patients with allergic rhinitis. Two extracts were prepared for diagnostic test with Cyn d proteins obtained from rural and urban environment. Skin prick test (SPT), nasal challenge test (NCT), and eosinophil count in nasal mucus were performed in 3 groups: healthy subjects without rhinitis, rhinitis with (+) Cyn d, and rhinitis with (-) Cyn d.
There was a 97% concordance in the positive and negative results of the SPT with the 2 extracts. However, Cyn d-urban extract generated larger wheals ( = .03) and a higher number of patients with rhinitis presented a positive NCT to this extract (n = 7 vs 14, = .04). Patients with positive NCT had a significant increase in eosinophils in mucus, but there was no difference between the extracts. The healthy controls did not react to the extracts tested in the skin or nasal test.
The findings suggest that the growth conditions in urban area of can generate changes in the protein extract and have clinical implications in patients with allergic rhinitis.
流行病学和实验研究表明，空气污染对人类健康有负面影响并改变环境。然而，空气污染继发的环境过敏原变化的临床意义鲜有研究。
探讨豚草（农村与城市地区）的生长条件是否会改变过敏性鼻炎患者的炎症反应。用从农村和城市环境中获得的豚草蛋白制备了两种提取物用于诊断测试。对三组进行皮肤点刺试验（SPT）、鼻激发试验（NCT）以及鼻黏液嗜酸性粒细胞计数：无鼻炎的健康受试者、豚草阳性（+）的鼻炎患者和豚草阴性（-）的鼻炎患者。
两种提取物的SPT阳性和阴性结果有97%的一致性。然而，城市豚草提取物产生的风团更大（P = 0.03），更多鼻炎患者对该提取物的NCT呈阳性（n = 7对14，P = 0.04）。NCT阳性的患者黏液中的嗜酸性粒细胞显著增加，但提取物之间无差异。健康对照者对皮肤或鼻试验中测试的提取物无反应。
研究结果表明，豚草在城市地区的生长条件可使蛋白提取物发生变化，并对过敏性鼻炎患者产生临床影响。
