Espinola-Klein C, Vosseler M, Abegunewardene N, Himmrich L, Schlosser A, Schuster C-J
Zentrum für Kardiologie/Kardiologie I, Universitätsmedizin der Johannes-Gutenberg-Universität, Langenbeckstr. 1, 55131, Mainz, Deutschland.
Gefäßzentrum/Angiologie, Helios Klinikum Erfurt, Erfurt, Deutschland.
Herz. 2019 Feb;44(1):40-44. doi: 10.1007/s00059-018-4774-3.
Atherosclerosis is a disease which affects the whole arterial vascular tree. In particular patients with peripheral arterial occlusive disease (PAOD) often suffer from additional atherosclerotic manifestations in other vascular territories. This has a direct impact on cardiovascular prognosis. Atherosclerosis is an inflammatory disease. A high inflammatory burden is associated with polyvascular atherosclerosis and also with the occurrence of cardiovascular events. Control of cardiovascular risk factors is crucial for the treatment of patients with polyvascular atherosclerosis. In addition, anticoagulation treatment is very important in patients with atherosclerosis. Moreover, exercise training is an important treatment option in PAOD patients not only to improve walking distance but also for multiple additional positive effects. So far the role of anti-inflammatory treatment is not clear and must be further elaborated by future clinical research.
动脉粥样硬化是一种影响整个动脉血管系统的疾病。特别是患有外周动脉闭塞性疾病（PAOD）的患者，常常在其他血管区域出现额外的动脉粥样硬化表现。这对心血管预后有直接影响。动脉粥样硬化是一种炎症性疾病。高炎症负荷与多血管动脉粥样硬化以及心血管事件的发生有关。控制心血管危险因素对于多血管动脉粥样硬化患者的治疗至关重要。此外，抗凝治疗在动脉粥样硬化患者中非常重要。而且，运动训练对于PAOD患者是一种重要的治疗选择，不仅可以改善步行距离，还具有多种其他积极作用。到目前为止，抗炎治疗的作用尚不清楚，必须通过未来的临床研究进一步阐明。
