Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Department of Pathology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
J Dermatol. 2019 Mar;46(3):263-266. doi: 10.1111/1346-8138.14750. Epub 2019 Jan 10.
Many women experience some skin reaction or trouble in their monthly menstrual cycle, including the exacerbation of pre-existing diseases and skin eruptions directly associated with sex hormones. We herein report a Japanese woman who experienced repeated systemic urticaria in her premenstrual period, and was diagnosed as having estrogen dermatitis based on a positive result of intradermal estrogen skin test. Of note, the expression of estrogen receptor-β was increased in small dermal vessels of this case as well as in those of patients with other inflammatory skin diseases. These results suggest that inflammation may induce estrogen receptor-β expression in small dermal vessels, which potentially modifies the pathological skin inflammation during the menstrual period, leading to the development of estrogen dermatitis.
许多女性在月经周期中会出现一些皮肤反应或问题，包括原有疾病的恶化和与性激素直接相关的皮肤疹。我们在此报告一例日本女性，她在月经前期反复出现全身性荨麻疹，并通过皮内雌激素皮肤试验阳性结果诊断为雌激素性皮炎。值得注意的是，该例患者及其他炎症性皮肤病患者的真皮小血管中雌激素受体-β的表达增加。这些结果表明，炎症可能诱导真皮小血管中雌激素受体-β的表达，从而潜在地改变月经期间的病理性皮肤炎症，导致雌激素性皮炎的发生。
