亚甲基四氢叶酸还原酶C677T基因多态性与糖尿病视网膜病变风险：中国人群的荟萃分析
Methylenetetrahydrofolate reductase C677T polymorphism and diabetic retinopathy risk: a meta-analysis of the Chinese population.
作者信息
Xu Wei-Hai, Zhuang Ying, Han Xiao, Yuan Zhi-Lan
机构信息
Department of Ophthalmology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Department of Ophthalmology, Binhai County People's Hospital, Yancheng, Jiangsu Province, China.
出版信息
J Int Med Res. 2020 Jan;48(1):300060518816834. doi: 10.1177/0300060518816834. Epub 2019 Jan 10.
OBJECTIVES
This study evaluated associations between methylenetetrahydrofolate reductase () C677T polymorphisms and diabetic retinopathy (DR) susceptibility within the Chinese population.
METHODS
Five databases (PubMed, EMBASE, Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure) were used for literature searches of open access articles from inception through April 2017.
RESULTS
Eight publications were identified involving 600 DR cases, 363 healthy controls, and 646 nondiabetic retinopathy (NDR) controls. There was a positive association between C677T polymorphisms and DR risk within the Chinese population (DR with NDR controls: T vs. C, odds ratio (OR): 2.14, 95% confidence interval (CI): 1.55–2.97; TT vs. CC, OR: 4.19, 95% CI: 2.09–8.41; TT + CT vs. CC, OR: 2.83, 95% CI: 1.86–4.40; TT vs. CC + CT, OR: 2.48, 95% CI: 1.52–4.05. DR with healthy controls: T vs. C, OR: 2.48, 95% CI: 1.99–3.09; TT vs. CC, OR: 4.92, 95% CI: 3.18–7.62; TT + CT vs. CC, OR: 3.22, 95% CI: 2.32–4.48; TT vs. CC + CT, OR: 3.11, 95% CI: 1.83–5.28). The association was similar in South China and North China, when stratifying by geographic areas.
CONCLUSION
C677T polymorphisms increase DR risk within the Chinese population.
目的
本研究评估了中国人群中亚甲基四氢叶酸还原酶（MTHFR）C677T基因多态性与糖尿病视网膜病变（DR）易感性之间的关联。
方法
使用五个数据库（PubMed、EMBASE、Web of Science、Cochrane图书馆、中国国家知识基础设施）对从创刊至2017年4月的开放获取文章进行文献检索。
结果
共识别出8篇出版物，涉及600例DR病例、363例健康对照和646例非糖尿病视网膜病变（NDR）对照。在中国人群中，MTHFR C677T基因多态性与DR风险呈正相关（DR与NDR对照：T与C相比，比值比（OR）：2.14，95%置信区间（CI）：1.55–2.97；TT与CC相比，OR：4.19，95%CI：2.09–8.41；TT + CT与CC相比，OR：2.83，95%CI：1.86–4.40；TT与CC + CT相比，OR：2.48，95%CI：1.52–4.05。DR与健康对照：T与C相比，OR：2.48，95%CI：1.99–3.09；TT与CC相比，OR：4.92，95%CI：3.18–7.62；TT + CT与CC相比，OR：3.22，95%CI：2.32–4.48；TT与CC + CT相比，OR：3.11，95%CI：1.83–5.28）。按地理区域分层时，中国南方和北方的关联相似。
结论
MTHFR C677T基因多态性增加了中国人群患DR的风险。
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