Department of Ophthalmology, The First Hospital of China Medical University, Shenyang, People's Republic of China.
PLoS One. 2012;7(9):e45264. doi: 10.1371/journal.pone.0045264. Epub 2012 Sep 20.
Although diabetic retinopathy (DR) is considered to be a major cause of blindness, this is the first meta-analysis to investigate the pooled prevalence of DR in mainland China.
METHODOLOGY/PRINCIPAL FINDINGS: We conducted a search of all English reports on population-based studies for the prevalence of DR using Medline, EMbase, Web of Science, Google (scholar), and all Chinese reports were identified manually and on-line using CBMDisc, Chongqing VIP database, and CNKI database. A meta-analysis was carried out. The fixed effects model or random effects model was used as a statistical test for homogeneity. Nineteen studies were included. The prevalence of DR, non-proliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR) in the pooled general population was 1.3% (95%CI: 0.5%-3.2%), 1.1% (95%CI: 0.6%-2.1%), and 0.1% (95%CI: 0.1%-0.3%), respectively, but was 23% (95%CI: 17.8%-29.2%), 19.1% (95%CI: 13.6%-26.3%), and 2.8% (95%CI: 1.9%-4.2%) in the diabetic group. The prevalence rate of DR in the pooled rural population was higher than that in the urban population, 1.6% (95%CI: 1.3%-2%), and the diabetic population, 29.1% (95%CI: 20.9%-38.9%). The prevalence of DR was higher in the Northern region compared with the Southern region.
CONCLUSIONS/SIGNIFICANCE: The prevalence of DR in mainland China appeared a little high, and varied according to area. NPDR was more common. This study highlights the necessity for DR screening in the rural areas of China.
虽然糖尿病视网膜病变（DR）被认为是失明的主要原因，但这是首次对中国大陆地区 DR 的患病率进行的荟萃分析。
方法/主要发现：我们使用 Medline、EMbase、Web of Science、Google（学术）检索了所有关于基于人群的 DR 患病率的英文报告，并手动和在线检索了中国的所有报告，使用了 CBMDisc、重庆 VIP 数据库和中国知网数据库。进行了荟萃分析。使用固定效应模型或随机效应模型作为同质性的统计检验。纳入了 19 项研究。总体人群中 DR、非增生性糖尿病视网膜病变（NPDR）和增生性糖尿病视网膜病变（PDR）的患病率分别为 1.3%（95%CI：0.5%-3.2%）、1.1%（95%CI：0.6%-2.1%）和 0.1%（95%CI：0.1%-0.3%），但在糖尿病患者中分别为 23%（95%CI：17.8%-29.2%）、19.1%（95%CI：13.6%-26.3%）和 2.8%（95%CI：1.9%-4.2%）。在 pooled rural population 中，DR 的患病率高于 pooled urban population，为 1.6%（95%CI：1.3%-2%），在 diabetic population 中，DR 的患病率为 29.1%（95%CI：20.9%-38.9%）。与南方地区相比，北方地区的 DR 患病率更高。
结论/意义：中国内地 DR 的患病率似乎略高，且因地区而异。NPDR 更为常见。本研究强调了在中国农村地区进行 DR 筛查的必要性。
