Department of Neurosurgery, Hospital Clínico San Carlos, Health Research Institute of the Hospital Clínico San Carlos, Madrid, Spain,
Toronto Western Research Institute, Krembil Discovery Tower, University Health Network, Toronto, Ontario, Canada.
Dement Geriatr Cogn Disord. 2019;47(1-2):19-28. doi: 10.1159/000493094. Epub 2019 Jan 10.
BACKGROUND/AIM: The prevalence of cognitive symptoms in recently diagnosed Parkinson's disease (PD) patients may be as high as 60%. We report a novel deep brain stimulation (DBS) strategy targeting both motor and cognitive symptoms.
A PD patient diagnosed with mild cognitive impairment underwent DBS surgery targeting the globus pallidus interna (GPi; to treat motor symptoms) and the nucleus basalis of Meynert (NBM; to treat cognitive symptoms) using a single electrode per hemisphere.
Compared to baseline, 2-month follow-up after GPi stimulation was associated with motor improvements, whereas partial improvements in cognitive functions were observed 3 months after the addition of NBM stimulation to GPi stimulation.
This case explores an available alternative for complete DBS treatment in PD, stimulating 2 targets at different frequencies with a single electrode lead.
背景/目的：新近诊断的帕金森病（PD）患者认知症状的患病率可能高达 60%。我们报告了一种针对运动和认知症状的新型深部脑刺激（DBS）策略。
一名被诊断为轻度认知障碍的 PD 患者接受了 DBS 手术，手术针对的是内苍白球（GPi；用于治疗运动症状）和内嗅核（NBM；用于治疗认知症状），每侧半球使用一个电极。
与基线相比，GPi 刺激后的 2 个月随访与运动改善相关，而在 GPi 刺激的基础上增加 NBM 刺激 3 个月后，认知功能有部分改善。
该病例探讨了 PD 患者 DBS 治疗的另一种可行选择，使用单个电极导联以不同频率刺激 2 个靶点。
