Department of Obstetrics and Gynecology, PEDEGO Research Unit, Medical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland.
Jean-Pierre Aubert Research Center, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Institut National de la Santé et de la Recherche Médicale, Lille, France; Fédération Hospitalière Universitaire, School of Medicine, University of Lille, Lille, France.
Fertil Steril. 2019 Mar;111(3):588-596.e1. doi: 10.1016/j.fertnstert.2018.11.028. Epub 2019 Jan 7.
To investigate plasma antimüllerian hormone (AMH) concentration and its relation to steroid hormone levels in pregnant women with polycystic ovary syndrome (PCOS) and controls at term.
Case-control study.
University-affiliated hospital.
PATIENT(S): A total of 74 pregnant women at term: 25 women with PCOS (aged 31.6 ± 3.9 years [mean ± standard deviation], body mass index 24.0 ± 3.9 kg/m2, mean gestational length 279 ± 9 days) and 49 controls (aged 31.7 ± 3.3 years, body mass index 24.0 ± 3.3 kg/m2, mean gestational length 281 ± 9 days).
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Plasma AMH and steroid hormone levels.
RESULT(S): Antimüllerian hormone, T, and androstenedione levels were higher in women with PCOS at term compared with controls, whereas estrogen and P levels were similar. The differences were pronounced in women carrying a female fetus. Testosterone and AMH levels correlated positively in both groups, but E levels only in women with PCOS.
CONCLUSION(S): Pregnant women with PCOS present with elevated AMH and androgen levels even at term, suggesting a hormonal imbalance during PCOS pregnancy. Differences were detected especially in pregnancies with a female fetus, raising the question of whether female pregnancies are more susceptible to AMH and steroid hormone actions.
研究多囊卵巢综合征（PCOS）孕妇和对照组足月孕妇的血浆抗缪勒管激素（AMH）浓度及其与甾体激素水平的关系。
病例对照研究。
大学附属医院。
共 74 例足月孕妇：25 例 PCOS 孕妇（年龄 31.6 ± 3.9 岁[均值 ± 标准差]，体重指数 24.0 ± 3.9 kg/m2，平均孕龄 279 ± 9 天）和 49 例对照组（年龄 31.7 ± 3.3 岁，体重指数 24.0 ± 3.3 kg/m2，平均孕龄 281 ± 9 天）。
无。
血浆 AMH 和甾体激素水平。
PCOS 孕妇足月时 AMH、T 和雄烯二酮水平高于对照组，而雌激素和孕酮水平相似。携带女胎的孕妇差异更为明显。两组中 AMH 和睾酮水平呈正相关，但仅在 PCOS 孕妇中与 E 水平相关。
即使在足月时，PCOS 孕妇也存在 AMH 和雄激素水平升高，表明 PCOS 妊娠期间存在激素失衡。在携带女胎的孕妇中尤其存在差异，这引发了 AMH 和甾体激素作用是否更易导致女胎妊娠的问题。
