Aversa Sara, Bellan Cristiana
Department of Medical Biotechnologies, Section of Pathology, University of Siena, 53100 Siena, Italy.
Case Rep Gastrointest Med. 2018 Dec 5;2018:6405125. doi: 10.1155/2018/6405125. eCollection 2018.
Thyroid transcription factor (TTF-1) is a tissue-specific nuclear transcription factor expressed developing thyroid, respiratory epithelium, and diencephalon. TTF-1 is thought to be expressed specifically in most thyroid tumors and in a significant subset of pulmonary neoplasms. However, recent studies on its expression in extrapulmonary carcinomas have demonstrated that TTF-1 is not as specific for lung and thyroid carcinomas as was previously thought: positivity of this marker can be observed, although much less frequently, in some carcinomas arising in other organs, such as the ovaries, endometrium, colon, and breast, as well as in some tumors of the central nervous system. Case reports of patients with TTF-1-positive colon adenocarcinoma are present in medical literature, but there are only a few cases of TTF-1-positive rectal adenocarcinoma. We present the case of a patient with rectal adenocarcinoma with lung metastasis found to be TTF-1-positive on immunohistochemistry. A review of the available literature is also included.
甲状腺转录因子（TTF-1）是一种组织特异性核转录因子，在发育中的甲状腺、呼吸道上皮和间脑中表达。TTF-1被认为在大多数甲状腺肿瘤和相当一部分肺肿瘤中特异性表达。然而，最近关于其在肺外癌中表达的研究表明，TTF-1对肺癌和甲状腺癌的特异性并不像之前认为的那样高：在其他器官发生的一些癌症中，如卵巢、子宫内膜、结肠和乳腺，以及一些中枢神经系统肿瘤中，虽然频率低得多，但也能观察到该标志物呈阳性。医学文献中有TTF-1阳性结肠腺癌患者的病例报告，但TTF-1阳性直肠腺癌的病例很少。我们报告一例直肠腺癌伴肺转移患者，免疫组化显示TTF-1阳性。本文还对现有文献进行了综述。
