[甲状腺转录因子-1（8G7G3/1）阳性结肠腺癌：诊断意义]

[TTF-1 (8G7G3/1) positive colon adenocarcinoma: diagnostic implications].

作者信息

Reis H G, Metz C H D, Baba H A, Bornfeld N, Schmid K W, Metz K A

机构信息

Institut für Pathologie und Neuropathologie, Universitätsklinikum Essen, Universität Duisburg-Essen, Hufelandstr. 55, 45122, Essen, Deutschland.

出版信息

Pathologe. 2011 Jul;32(4):349-51. doi: 10.1007/s00292-010-1414-y.

DOI:10.1007/s00292-010-1414-y

PMID:21161231

Abstract

Immunohistochemical evaluation of primary and secondary (adeno-) carcinomas of the lung often includes utilisation of two different clones (8G7G3/1 or SPT24) of TTF-1 (thyroid transcription factor 1) antibodies. In a subgroup of adenocarcinomas with a primary site other than the lung a positive reaction of clone SPT24 and also of clone 8G7G3/1 is described. We report on a patient with TTF-1 (clone 8G7G3/1) positive adenocarcinoma of the colon with metastases to the eye and lung and discuss TTF-1 based diagnostic considerations.

摘要

肺原发性和继发性（腺）癌的免疫组织化学评估通常包括使用两种不同克隆（8G7G3/1或SPT24）的甲状腺转录因子1（TTF-1）抗体。在原发部位并非肺部的腺癌亚组中，已描述了克隆SPT24以及克隆8G7G3/1的阳性反应。我们报告了1例患有转移至眼部和肺部的TTF-1（克隆8G7G3/1）阳性结肠癌患者，并讨论基于TTF-1的诊断考量。