TTF-1在直肠腺癌中的表达：一例病例报告及文献综述
TTF-1 Expression in Rectal Adenocarcinoma: A Case Report and Review of the Literature.
作者信息
Belalcazar Astrid, Krishnamurti Uma, Shaib Walid
机构信息
Department of Hematology and Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA.
Department of Pathology, Emory University, Atlanta, GA, USA.
出版信息
Case Rep Oncol. 2016 Nov 18;9(3):747-751. doi: 10.1159/000450973. eCollection 2016 Sep-Dec.
Abstract
Thyroid transcription factor 1 (TTF-1) is considered a highly sensitive and specific marker for primary lung adenocarcinoma. However, in recent years retrospective studies of tumor samples have confirmed that, although rare, TTF-1 can also be expressed in colorectal adenocarcinoma. There are a few case reports of patients with TTF-1-positive colon adenocarcinoma in the medical literature but none of TTF-1-positive rectal adenocarcinoma. Here, we present a case of rectal adenocarcinoma with lung metastasis found to be TTF-1 positive on immunohistochemistry. A review and discussion of the available literature is also included.
摘要
甲状腺转录因子1（TTF-1）被认为是原发性肺腺癌的一种高度敏感和特异的标志物。然而，近年来对肿瘤样本的回顾性研究证实，虽然罕见，但TTF-1也可在结直肠癌中表达。医学文献中有几例TTF-1阳性结肠腺癌患者的病例报告，但没有TTF-1阳性直肠腺癌的报告。在此，我们报告一例直肠腺癌伴肺转移患者，免疫组化显示TTF-1阳性。本文还包括对现有文献的综述和讨论。
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