新型半夹心型钌(ii)配合物作为癌细胞中的蛋白质合成抑制剂。
New half-sandwich ruthenium(ii) complexes as proteosynthesis inhibitors in cancer cells.
机构信息
Departamento de Química Inorgánica, Facultad de Química, Biomedical Research Institute of Murcia (IMIB-Arrixaca-UMU), Universidad de Murcia, E-30071 Murcia, Spain.
CIMUS, Universidad de Santiago de Compostela, Avenida Barcelona s/n, 15782, Santiago de Compostela, Spain.
出版信息
Chem Commun (Camb). 2019 Jan 25;55(8):1140-1143. doi: 10.1039/c8cc09211g. Epub 2019 Jan 11.
Half-sandwich ruthenium(ii) complexes [(η-p-cymene)Ru(C^N)-(X)] (X = Cl, py or 4-NMe-py) containing a cyclometalated 2-ppy or 1-ppz with a non-coordinated CHO group as a handle for further functionalization have been synthesized to achieve selective cytotoxicity to cancer cells, the more potent compounds acting as proteosynthesis inhibitors; this is a new mode of action for half-sandwich metal complexes.
含一个非配位 CHO 基团的半三明治钌(ii)配合物 [(η-p-cymene)Ru(C^N)-(X)] (X = Cl, py 或 4-NMe-py)，其中一个环金属化的 2-ppy 或 1-ppz 作为进一步功能化的手柄，已被合成出来以实现对癌细胞的选择性细胞毒性，更有效的化合物作为蛋白质合成抑制剂；这是半三明治金属配合物的一种新作用模式。
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