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新型钌（II）配合物[Ru(-Cymene)ClL]的合成与表征及其对宫颈癌细胞系 HeLa 的细胞毒性。

Synthesis and Characterization of New Ruthenium (II) Complexes of Stoichiometry [Ru(-Cymene)ClL] and Their Cytotoxicity against HeLa-Type Cancer Cells.

机构信息

Departamento de Ingeniería Química, Facultad de Química, Campus Regional de Excelencia "Campus Mare Nostrum", Universidad de Murcia, 30071 Murcia, Spain.

Departamento de Ingeniería Química y Medioambiental, ETSII, Universidad Politécnica de Cartagena, 30203 Cartagena, Spain.

出版信息

Molecules. 2022 Oct 26;27(21):7264. doi: 10.3390/molecules27217264.

DOI:10.3390/molecules27217264
PMID:36364091
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9654852/
Abstract

When the [Ru(-cymene)(μ-Cl)Cl] complex is made to react, in dichloromethane, with the following ligands: 2-aminobenzonitrile (2abn), 4-aminobenzonitrile (4abn), 2-aminopyridine (2ampy) and 4-aminopyridine (4ampy), after addition of hexane, the following compounds are obtained: [Ru(-cymene)Cl(2abn)] , [Ru(-cymene)Cl(4abn)] , [Ru(-cymene)Cl(2ampy] and [Ru(-cymene)Cl(μ-(4ampy)] . All the compounds are characterized by elemental analysis of carbon, hydrogen and nitrogen, proton nuclear magnetic resonance, COSY H-H, high-resolution mass spectrometry (ESI), thermogravimetry and single-crystal X-ray diffraction (the crystal structure of is reported and compared with the closely related literature of ). The cytotoxicity effects of complexes were described for cervical cancer HeLa cells via 3-(4.5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide (MTT) assay. The results demonstrate a low in vitro anticancer potential of the complexes.

摘要

当 [Ru(-cymene)(μ-Cl)Cl] 配合物在二氯甲烷中与以下配体反应时：2-氨基苯甲腈 (2abn)、4-氨基苯甲腈 (4abn)、2-氨基吡啶 (2ampy) 和 4-氨基吡啶 (4ampy)，在加入正己烷后，得到以下化合物：[Ru(-cymene)Cl(2abn)]、[Ru(-cymene)Cl(4abn)]、[Ru(-cymene)Cl(2ampy)] 和 [Ru(-cymene)Cl(μ-(4ampy)]。所有化合物均通过元素分析碳、氢和氮、质子核磁共振、COSY H-H、高分辨率质谱 (ESI)、热重分析和单晶 X 射线衍射进行了表征（报道了的晶体结构并与密切相关的文献进行了比较）。通过 3-(4.5-二甲基噻唑-2-基)-2.5-二苯基四氮唑溴化物 (MTT) 测定法，描述了配合物对宫颈癌 HeLa 细胞的细胞毒性作用。结果表明，这些配合物具有较低的体外抗癌潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd52/9654852/45da8667bf27/molecules-27-07264-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd52/9654852/96145c7b7979/molecules-27-07264-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd52/9654852/482fe5ab2276/molecules-27-07264-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd52/9654852/308175acc81d/molecules-27-07264-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd52/9654852/e3f764759669/molecules-27-07264-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd52/9654852/3a7130a5eb30/molecules-27-07264-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd52/9654852/45da8667bf27/molecules-27-07264-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd52/9654852/96145c7b7979/molecules-27-07264-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd52/9654852/482fe5ab2276/molecules-27-07264-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd52/9654852/308175acc81d/molecules-27-07264-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd52/9654852/e3f764759669/molecules-27-07264-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd52/9654852/3a7130a5eb30/molecules-27-07264-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd52/9654852/45da8667bf27/molecules-27-07264-g006.jpg

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