荧光点亮探针用于检测蛋白质聚集物。
Fluorescent Light-up Probe for the Detection of Protein Aggregates.
机构信息
Department of chemistry and QOPNA, University of Aveiro, Campus of Santiago, Aveiro, Portugal.
Department of Medical Sciences and Institute of Biomedicine, IBiMED, University of Aveiro, Agras do Crasto, Aveiro, Portugal.
出版信息
Chem Asian J. 2019 Mar 15;14(6):859-863. doi: 10.1002/asia.201801606. Epub 2019 Jan 11.
A fluorescent dye was decorated with water-soluble pyridinium groups in order to be applied in the detection of cyclodextrins or DNA. The dye displays an enhancement of its emission intensity when the internal rotations are restricted due to the formation of an inclusion complex with cyclodextrins or upon interaction with DNA. In vivo, the fluorescent probe can stain protein aggregates with a selectivity comparable to the widely used Proteostat®.
一种荧光染料被修饰上水溶性的吡啶基团，以便应用于环糊精或 DNA 的检测。当内部旋转因与环糊精形成包合物或与 DNA 相互作用而受到限制时，该染料的发射强度会增强。在体内，荧光探针可以对蛋白质聚集体进行染色，其选择性可与广泛使用的 Proteostat®相媲美。
Zotero 插件