Yang Gaoyi, Fang Jianhua, Yu Tianzhuo, Zhang Ying, Zhang Wenzhi, Zhao Dan, Xu Jianping, Wang Caifen
1 Department of Ultrasonography, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang, P.R. China.
2 Department of Ultrasonography, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China.
J Int Med Res. 2019 Apr;47(4):1512-1520. doi: 10.1177/0300060518821818. Epub 2019 Jan 11.
This study was performed to assess the feasibility, effectiveness, and safety of percutaneous ultrasound (US)-guided laser ablation (LA) for the treatment of cervical tuberculous lymphadenitis (CTBL).
We retrospectively reviewed 11 patients with CTBL (mean age, 32.0 ± 8.6 years; range, 18-47 years) who underwent percutaneous US-guided LA from June 2014 to December 2016 with a subsequent 12-month follow-up. We assessed the mean volume reduction and contrast-enhanced US (CEUS) changes of the target lymph nodes as well as the tolerability and adverse effects of LA.
The mean ablation energy was 522 ± 312 J (range, 204-1317 J). All 17 enrolled target lymph nodes were completely non-enhanced after LA treatment as detected by CEUS, indicating complete ablation of all lymph nodes (100%). The target lymph nodes significantly decreased in volume by a mean of 74.0% ± 15.6% from baseline to 12 months after LA. The LA procedure was well tolerated, and none of the 11 patients developed severe complications during the 12-month follow-up.
Percutaneous US-guided LA for the treatment of CTBL exhibits good tolerability, minimal invasiveness, and few adverse effects. Further investigations with larger sample sizes and longer follow-up periods are warranted to confirm these findings.
本研究旨在评估经皮超声引导下激光消融术治疗颈淋巴结结核（CTBL）的可行性、有效性及安全性。
回顾性分析2014年6月至2016年12月期间接受经皮超声引导下激光消融术并随后进行12个月随访的11例颈淋巴结结核患者（平均年龄32.0±8.6岁；范围18 - 47岁）。评估目标淋巴结的平均体积缩小情况、超声造影（CEUS）变化以及激光消融术的耐受性和不良反应。
平均消融能量为522±312 J（范围204 - 1317 J）。经CEUS检测，所有17个纳入的目标淋巴结在激光消融治疗后均完全无强化，表明所有淋巴结均完全消融（100%）。从基线到激光消融术后12个月，目标淋巴结体积平均显著缩小74.0%±15.6%。激光消融术耐受性良好，11例患者在12个月随访期间均未发生严重并发症。
经皮超声引导下激光消融术治疗颈淋巴结结核耐受性良好、创伤小且不良反应少。需要进一步开展更大样本量、更长随访期的研究以证实这些发现。
