The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
Department of Oral and Maxillofacial Head Neck Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
Histol Histopathol. 2019 Jul;34(7):803-810. doi: 10.14670/HH-18-084. Epub 2019 Jan 11.
Glycoprotein non-metastatic protein B (GPNMB) is a transmembrane glycoprotein that is highly expressed in several malignancies compared with its expression in matched healthy tissues. The aim of this study was to investigate the clinical characteristics and prognostic value of GPNMB expression in tumor tissue derived from a cohort of patients with head and neck squamous cell carcinoma (HNSCC). GPNMB expression in human HNSCC, oral dysplasia and normal mucosal tissue was evaluated by immunohistochemistry (IHC). The correlations of GPNMB expression with the clinical characteristics of HNSCC were assessed by one-way ANOVA and t test analyses. Survival data were analyzed using Kaplan-Meier analysis and the Cox proportional hazards model. GPNMB was highly expressed in HNSCC tissue compared with dysplasia and normal mucosal tissue. Additionally, a high level of GPNMB expression in HNSCC was associated with poor prognosis (P<0.01). In the analysis of tumor-node-metastasis (TNM) staging, a high GPNMB expression level in HNSCC tissue, as well as metastatic lymph node tissue, correlated with an advanced N stage. In conclusion, GPNMB was overexpressed in human HNSCC tissue and predicted poor prognosis in human HNSCC tissue. In addition, GPNMB expression was closely correlated with N stage in patients with HNSCC.
糖蛋白非转移性蛋白 B（GPNMB）是一种跨膜糖蛋白，与匹配的健康组织相比，在几种恶性肿瘤中高表达。本研究旨在探讨 GPNMB 在头颈部鳞状细胞癌（HNSCC）患者肿瘤组织中的表达的临床特征和预后价值。通过免疫组织化学（IHC）评估 GPNMB 在人 HNSCC、口腔发育不良和正常黏膜组织中的表达。通过单因素方差分析和 t 检验分析评估 GPNMB 表达与 HNSCC 临床特征的相关性。使用 Kaplan-Meier 分析和 Cox 比例风险模型分析生存数据。与发育不良和正常黏膜组织相比，GPNMB 在 HNSCC 组织中高表达。此外，HNSCC 中高水平的 GPNMB 表达与预后不良相关（P<0.01）。在肿瘤-淋巴结-转移（TNM）分期分析中，HNSCC 组织和转移性淋巴结组织中高 GPNMB 表达水平与 N 期较晚相关。总之，GPNMB 在人 HNSCC 组织中过度表达，并预测人 HNSCC 组织中的预后不良。此外，GPNMB 表达与 HNSCC 患者的 N 期密切相关。
