Department of Biomarkers for Early Detection of Cancer, National Cancer Center Research Institute, Tokyo, Japan.
Department of Otorhinolaryngology, Juntendo University Faculty of Medicine, Tokyo, Japan.
Anticancer Res. 2021 Feb;41(2):1089-1099. doi: 10.21873/anticanres.14867.
BACKGROUND/AIM: Prognosis plays a vital role in head and neck squamous cell carcinoma (HNSCC) patient management and decision-making. This study aimed to identify the role of BP180 as a prognostic factor in HNSCC.
Protein expression of bullous pemphigoid antigen II (BP180) was verified by immunohistochemistry (IHC) in a tissue microarray study of 202 cases.
IHC analysis revealed that protein expression of BP180 among HNSCC patients differed significantly in the presence and absence of neural invasion, and according to T status in laryngeal and pharyngeal cancer subgroups. Overall survival and multivariate analysis showed that positive BP180-IHC and advanced clinical stage were significant independent positive predictors of mortality in HNSCC patients. In addition, in the oral cancer subgroup, independent positive predictors were positive BP180-IHC, advanced N status and neural invasion. In laryngeal and pharyngeal cancer subgroups, predictors were positive BP180-IHC and advanced clinical stage.
BP180 is a prognostic factor in head and neck squamous cell carcinoma.
背景/目的：预后在头颈部鳞状细胞癌（HNSCC）患者的管理和决策中起着至关重要的作用。本研究旨在确定 BP180 作为 HNSCC 预后因素的作用。
通过免疫组织化学（IHC）在 202 例组织微阵列研究中验证大疱性类天疱疮抗原 II（BP180）的蛋白表达。
IHC 分析显示，在存在和不存在神经浸润以及喉癌和咽癌亚组的 T 分期方面，HNSCC 患者的 BP180 蛋白表达存在显著差异。总体生存和多因素分析表明，BP180-IHC 阳性和临床分期较晚是 HNSCC 患者死亡的显著独立阳性预测因子。此外，在口腔癌亚组中，独立的阳性预测因子是 BP180-IHC 阳性、N 分期较晚和神经浸润。在喉癌和咽癌亚组中，预测因子是 BP180-IHC 阳性和临床分期较晚。
BP180 是头颈部鳞状细胞癌的预后因素。
