新西兰小鼠体内一种对解离的小脑细胞具有细胞毒性的天然存在抗体。
A naturally occurring antibody in New Zealand mice cytotoxic to dissociated cerebellar cells.
作者信息
Harbeck R J, Hoffman A A, Hoffman S A, Shucard D W, Carr R I
出版信息
Clin Exp Immunol. 1978 Feb;31(2):313-20.
A spontaneously occurring antibody cytotoxic to dissociated cells of the neonate mouse cerebellum was found in the sera of some New Zealand (NZ) mice. No significant activity was found in the sera of six non-autoimmune mouse strains. The degree of cytotoxicity was similar towards both allogeneic and syngeneic cells. Absorption of the cytotoxic sera with brain and kidney homogenates removed the reactivity, while liver removed less reactivity. Absorptions with thymocytes and several other tissue homogenates and cells had no effect on the cytotoxicity levels, nor was there a correlation between the levels of thymocytotoxicity and cerebellar cell cytotoxicity. The antibody cytotoxic for cerebellar cells could not be demonstrated in the cerebrospinal fluid (CSF) of any mice examined, including a mouse with high serum cytotoxic levels. Gel filtration of reactive sera indicated that the antibody is of the IgM class.
在一些新西兰（NZ）小鼠的血清中发现了一种对新生小鼠小脑解离细胞具有细胞毒性的自发产生抗体。在六种非自身免疫性小鼠品系的血清中未发现明显活性。对同种异体和同基因细胞的细胞毒性程度相似。用脑和肾匀浆吸收细胞毒性血清可消除反应性，而肝脏吸收后反应性降低较少。用胸腺细胞和其他几种组织匀浆及细胞吸收对细胞毒性水平无影响，胸腺细胞毒性水平与小脑细胞毒性之间也无相关性。在所检查的任何小鼠的脑脊液（CSF）中均未证实存在对小脑细胞具有细胞毒性的抗体，包括一只血清细胞毒性水平较高的小鼠。对反应性血清进行凝胶过滤表明该抗体属于IgM类。
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