Chaudhry Asad Rehman, El Khoury Mona, Gotra Akshat, Eslami Zohreh, Omeroglu Atilla, Omeroglu-Altinel Gulbeyaz, Chaudhry Shazia Hira, Mesurolle Benoît
1 Department of Radiology, McGill University Health Centre , Montreal, QC , Canada.
2 Department of Radiology, Centre Hospitalier Universitaire de Montreal, Hotel-Dieu de Montreal , Montreal, QC , Canada.
Br J Radiol. 2019 Mar;92(1095):20180810. doi: 10.1259/bjr.20180810. Epub 2019 Jan 11.
: A cross-sectional study identified cases of mucinous breast carcinoma from pathology records (2004-2012). Two radiologists classified imaging features by consensus and two pathologists classified cases into pure or mixed subtypes. Bi-variable analyses were performed using relevant statistical tests.
: We identified 80 lesions in 77 female patients (median age 65 years, range 29-88): 58 lesions on mammograhy, 72 on ultrasound, and 25 on MRI. Statistically significant findings (p < 0.05) are as follows. On mammography, tumour margins tended to be indistinct (12, 48%) and spiculated (11, 44%) for pure and mixed lesions, respectively. Pure mucinous masses were less microcalcified (23, 77%) and mixed masses equally so. On ultrasound, pure tumours tended towards an irregular or oval shape (44, 42%) with mixed tumours having an irregular shape (78%). More pure tumours (53%) had posterior acoustic enhancement than mixed lesions (33%), and all pure tumours lacked posterior acoustic shadowing. Pure lesions had a heterogeneous echo pattern more than mixed tumours (78% vs 39%). On MRI, pure tumours tended towards a persistent kinetic curve (42%) whereas mixed tumours predominantly had a washout pattern (75%). Most pure tumours were T hyperintense (83%) whereas mixed lesions were T2 isointense or hyperintense (61%, 23%), respectively.
: An analysis of imaging features can help to infer underlying histology of pure and mixed forms of mucinous breast carcinoma.
: Pure mucinous carcinomas present less suspicious imaging features than mixed mucinous carcinomas and could be mistaken for non malignant lesions. An imaging analysis of mucinous breast carcinoma can help infer their underlying histology.
一项横断面研究通过病理记录（2004 - 2012年）确定黏液性乳腺癌病例。两名放射科医生通过共识对影像特征进行分类，两名病理科医生将病例分为纯合型或混合型亚型。使用相关统计检验进行双变量分析。
我们在77名女性患者（中位年龄65岁，范围29 - 88岁）中识别出80个病灶：乳腺X线摄影发现58个病灶，超声发现72个病灶，MRI发现25个病灶。具有统计学意义的结果（p < 0.05）如下。在乳腺X线摄影中，纯合型和混合型病灶的肿瘤边缘分别倾向于不清楚（12个，48%）和有毛刺（11个，44%）。纯黏液性肿块微钙化较少（23个，77%），混合型肿块情况相同。在超声检查中，纯肿瘤倾向于不规则或椭圆形（44个，42%），混合型肿瘤呈不规则形状（78%）。纯肿瘤有后方回声增强的比例高于混合型病灶（53% 对33%），并且所有纯肿瘤均无后方声影。纯病灶的回声模式比混合型肿瘤更不均匀（78% 对39%）。在MRI上，纯肿瘤倾向于持续动态曲线（42%），而混合型肿瘤主要表现为廓清模式（75%）。大多数纯肿瘤在T2加权像上呈高信号（83%），而混合型病灶分别为T2等信号或高信号（61%，23%）。
对影像特征的分析有助于推断纯合型和混合型黏液性乳腺癌的潜在组织学类型。
纯黏液性癌的影像特征比混合型黏液性癌的可疑程度低，可能被误诊为非恶性病变。黏液性乳腺癌的影像分析有助于推断其潜在组织学类型。
