a College of Public Health , Zhengzhou University , Zhengzhou , Henan , China.
b Henan Key Laboratory of Tumor Epidemiology , Zhengzhou , Henan , China.
Int J Food Sci Nutr. 2019 Aug;70(5):519-529. doi: 10.1080/09637486.2018.1551337. Epub 2019 Jan 11.
The association between coffee consumption and pancreatic cancer risk has been extensively studied; however, there is no consistent conclusion. Therefore, this meta-analysis study sought to evaluate dose-response relationship between them. A search was conducted using the PubMed and Web of Science databases. Thirteen high-quality cohort studies were identified, involving in 959,992 study participants and 3831 pancreatic cancer cases. Comparing the highest with lowest categories of coffee intake, the pooled relative risk (RR) was 1.08 (95% CI 0.94-1.25). For dose-response analysis, no evidence of a nonlinear dose-response association between coffee consumption and pancreatic cancer ( for nonlinearity =0.171) was found. The risk of pancreatic cancer was increased by 5.87% (RR =1.06, 95% CI 1.05-1.07) with the increment of one cup/day. Coffee consumption was identified to be related with the increasing risk of pancreatic cancer in a dose-response manner. Nevertheless, further mechanistic studies are needed to clarify the concerned issues.
咖啡摄入与胰腺癌风险之间的关联已经得到广泛研究，但尚无一致结论。因此，本荟萃分析旨在评估两者之间的剂量-反应关系。使用 PubMed 和 Web of Science 数据库进行了检索。共确定了 13 项高质量的队列研究，涉及 959992 名研究参与者和 3831 例胰腺癌病例。比较咖啡摄入量最高和最低组，汇总的相对风险（RR）为 1.08（95%CI 0.94-1.25）。对于剂量-反应分析，未发现咖啡摄入与胰腺癌之间存在非线性剂量-反应关联（非线性=0.171）。每天增加一杯咖啡，患胰腺癌的风险增加 5.87%（RR=1.06，95%CI 1.05-1.07）。咖啡摄入与胰腺癌风险呈剂量-反应关系。然而，需要进一步的机制研究来阐明相关问题。
