Nie Kechao, Xing Zhihua, Huang Wei, Wang Weihao, Liu Weiping
Institute of Integrated Medicine, Central South University, Xiangya Hospital, Changsha, China -
Minerva Med. 2016 Aug;107(4):270-8.
Inconsistent results on the relationship between coffee consumption and pancreatic cancer risk has been reported in both epidemiological studies and previous meta-analyses. This updated meta-analysis was conducted to assess the association of coffee intake with pancreatic cancer risk.
We evaluated the relationship of coffee ingestion and pancreatic cancer risk by performing a meta-analysis of prospective cohort studies and made an explicit document search in the PubMed database before November 2015. We also obtained prospective cohort studies of previous meta-analyses. A random-effects model was used for pooling overall relative risk. Twenty articles of coffee ingestion and pancreatic cancer were contained in our meta-analysis.
The summary relative risk (RR) of pancreatic cancer and coffee intake of the highest compared with lowest category was 0.99 (95% CI=0.81-1.21), with statistically moderate heterogeneity (I2=47.9%, P=0.008). The heterogeneity reduced to I2=38.5% after excluding one study, and the RR was 1.06 (95% CI=0.94-1.20). The relationships of coffee intake and pancreatic risk did not modified by geographic areas, sex of participants, number of cases, follow-up years, and the number of adjusted confounders.
Dose-response analysis indicated that every one-cup increase in coffee consumption was associated with an 1% increase in pancreatic cancer risk. No statistically significant publication biases existed. Coffee consumption may weakly increase the risk of pancreatic cancer.
在流行病学研究和先前的荟萃分析中，关于咖啡消费与胰腺癌风险之间的关系，结果并不一致。本更新的荟萃分析旨在评估咖啡摄入量与胰腺癌风险之间的关联。
我们通过对前瞻性队列研究进行荟萃分析，评估咖啡摄入与胰腺癌风险的关系，并于2015年11月之前在PubMed数据库中进行了明确的文献检索。我们还获取了先前荟萃分析中的前瞻性队列研究。采用随机效应模型汇总总体相对风险。我们的荟萃分析纳入了20篇关于咖啡摄入与胰腺癌的文章。
与最低类别相比，最高类别咖啡摄入量与胰腺癌的汇总相对风险（RR）为0.99（95%置信区间=0.81-1.21），具有统计学上中等程度的异质性（I²=47.9%，P=0.008）。排除一项研究后，异质性降至I²=38.5%，RR为1.06（95%置信区间=0.94-1.20）。咖啡摄入量与胰腺癌风险的关系不受地理区域、参与者性别、病例数、随访年限和调整后的混杂因素数量的影响。
剂量反应分析表明，咖啡消费量每增加一杯，胰腺癌风险增加1%。不存在统计学上显著的发表偏倚。咖啡消费可能会轻微增加胰腺癌风险。
