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用于个性化精准医学中多组学进展的多重检测

Multiplex assay for multiomics advances in personalized-precision medicine.

作者信息

Popa Maria-Linda, Albulescu Radu, Neagu Monica, Hinescu Mihail Eugen, Tanase Cristiana

机构信息

a Biochemistry-Proteomics Department , Victor Babes National Institute of Pathology , Bucharest , Romania.

b Cellular and Molecular Biology and Histology Department , "Carol Davila" University of Medicine and Pharmacy , Bucharest , Romania.

出版信息

J Immunoassay Immunochem. 2019;40(1):3-25. doi: 10.1080/15321819.2018.1562940. Epub 2019 Jan 11.

Abstract

Building the future of precision medicine is the main focus in cancer domain. Clinical trials are moving toward an array of studies that are more adapted to precision medicine. In this domain, there is an enhanced need for biomarkers, monitoring devices, and data-analysis methods. Omics profiling using whole genome, epigenome, transcriptome, proteome, and metabolome can offer detailed information of the human body in an integrative manner. Omes profiles reflect more accurately real-time physiological status. Personalized omics analyses both disease as a whole and the main disease processes, for a better understanding of the individualized health. Through this, multi-omic approaches for health monitoring, preventative medicine, and personalized treatment can be targeted simultaneously and can lead clinicians to have a comprehensive view on the diseasome.

摘要

构建精准医学的未来是癌症领域的主要关注点。临床试验正朝着一系列更适应精准医学的研究方向发展。在这个领域,对生物标志物、监测设备和数据分析方法的需求日益增加。使用全基因组、表观基因组、转录组、蛋白质组和代谢组的组学分析能够以综合的方式提供人体的详细信息。组学图谱能更准确地反映实时生理状态。个性化组学分析整体疾病以及主要疾病过程,以便更好地了解个体健康状况。通过这种方式,可以同时针对健康监测、预防医学和个性化治疗的多组学方法,使临床医生能够对疾病组有全面的认识。

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