Ophthalmic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York.
Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York.
Retina. 2020 Apr;40(4):758-764. doi: 10.1097/IAE.0000000000002438.
To evaluate the subfoveal choroidal thickness (SFCT) and vascular architecture in the fellow eyes of patients with circumscribed choroidal hemangioma (CCH).
In this retrospective observational study, patients were selected from outpatient ophthalmology clinics at the Memorial Sloan Kettering Cancer Center and Vitreous Retina Macula Consultants of New York. Subfoveal choroidal thickness was measured using enhanced depth imaging spectral domain optical coherence tomography from the outer portion of Bruch membrane to the choroidal-scleral interface. Choroidal vascular architecture was qualitatively examined. The main outcome measure was SFCT in fellow eyes of patients with CCH, which was compared with an age- and gender-matched control group.
Thirty-one fellow eyes (15 right eyes and 16 left eyes) of patients with CCH (23 males and 8 females) were examined. The fellow eye had a mean SFCT of 361.2 ± 99.9 μm compared with 252.0 ± 77.6 μm in the control group (P < 0.0001). Vascular architecture was disorganized in 13 (42%) fellow eyes and 1 (3%) control eye (P < 0.0001), with no apparent gradient of vessel sizes or discrete choroidal layers. The normal association between older age and a thinner choroid existed in control eyes but not in fellow eyes. Hemangioma thickness measured by ultrasound and the presence of subfoveal fluid in the CCH eye did not correlate with the fellow-eye SFCT.
In patients with CCH, fellow eyes had thicker SFCT when compared with age- and gender-matched control eyes. Choroidal architecture was often irregular, without segmented vascular layers. These findings suggest that inherent choroidal changes may exist in patients with CCH.
评估局限性脉络膜血管瘤（CCH）患者对侧眼的中心凹下脉络膜厚度（SFCT）和血管结构。
在这项回顾性观察研究中，患者选自纪念斯隆凯特琳癌症中心和纽约玻璃体视网膜黄斑病顾问的门诊眼科诊所。使用增强深度成像谱域光学相干断层扫描从 Bruch 膜的外部到脉络膜 - 巩膜界面测量中心凹下脉络膜厚度。定性检查脉络膜血管结构。主要观察指标为 CCH 患者对侧眼的 SFCT，并与年龄和性别匹配的对照组进行比较。
检查了 31 只 CCH 患者（23 名男性和 8 名女性）的对侧眼（15 只右眼和 16 只左眼）。对侧眼的平均 SFCT 为 361.2 ± 99.9μm，而对照组为 252.0 ± 77.6μm（P < 0.0001）。13 只（42%）对侧眼和 1 只（3%）对照组的血管结构紊乱（P < 0.0001），没有明显的血管大小梯度或离散的脉络膜层。在对照组中，年龄较大与脉络膜较薄之间存在正常的关联，但在对侧眼中不存在。超声测量的血管瘤厚度和 CCH 眼中的中心凹下积液与对侧眼 SFCT 无关。
与年龄和性别匹配的对照组相比，CCH 患者的对侧眼中心凹下脉络膜厚度较厚。脉络膜结构通常不规则，没有分段的血管层。这些发现表明，CCH 患者可能存在固有脉络膜变化。
