a Department of Radiation Oncology , Fudan University Shanghai Cancer Center , Shanghai , China.
b Department of Nutrition , Fudan University Shanghai Cancer Center , Shanghai , China.
Nutr Cancer. 2018 Nov-Dec;70(8):1299-1307. doi: 10.1080/01635581.2018.1557222. Epub 2019 Jan 11.
Weight loss during chemoradiotherapy is a major problem in patients with head and neck cancer. The aim of this study was to evaluate the effect of ONS on weight, nutritional status and quality of life (QOL) in patients with loco-regionally advanced nasopharyngeal cancer (NPC) undergoing chemoradiotherapy.
Patients with locally advanced NPC treated at a tertiary hospital in China prior to curative chemoradiotherapy were eligible for this exploratory randomized study. Patients were assigned to either the intervention or the control group based on a computer-generated randomization sequence. The intervention group commenced ONS at the start of chemoradiotherapy. Outcomes included body weight, BMI, nutritional status and QOL.
From June 2015 to June 2016, 50 patients with NPC were randomized to intervention and 50 to the control group. Patients in the ONS group had a higher body weight at the end of chemoradiotherapy (59.11 kg vs 58.14 kg, p = 0.036). A higher BMI and prealbumin were observed in the ONS group (p = 0.021 and p = 0.048, respectively). No other differences were found for nutritional status, QOL or clinical outcomes.
ONS had beneficial outcomes in terms of reducing weight loss, minimizing BMI decrease and increasing protein intake in loco-regionally advanced NPC patients during chemoradiotherapy.
在头颈部癌症患者中，化疗和放疗期间的体重减轻是一个主要问题。本研究的目的是评估 ONS 对接受放化疗的局部晚期鼻咽癌（NPC）患者的体重、营养状况和生活质量（QOL）的影响。
在中国一家三级医院接受根治性放化疗的局部晚期 NPC 患者有资格参加这项探索性随机研究。根据计算机生成的随机序列将患者分配到干预组或对照组。干预组在放化疗开始时开始 ONS。结局包括体重、BMI、营养状况和 QOL。
2015 年 6 月至 2016 年 6 月，50 例 NPC 患者被随机分配到干预组和对照组。ONS 组患者在放化疗结束时体重更高（59.11kg 比 58.14kg，p=0.036）。ONS 组的 BMI 和前白蛋白更高（p=0.021 和 p=0.048，分别）。在营养状况、QOL 或临床结局方面没有发现其他差异。
ONS 对局部晚期 NPC 患者在放化疗期间减少体重减轻、最大限度地减少 BMI 下降和增加蛋白质摄入具有有益的效果。
