Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences (CAAS), China; Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture, Lanzhou, China; Key Laboratory of New Animal Drug Project of Gansu Province, Lanzhou, China.
Zhang Ye Wan He Grass Planting and Animal Husbandry Science & Technology Development Co., Ltd., China.
Regul Toxicol Pharmacol. 2019 Apr;103:21-33. doi: 10.1016/j.yrtph.2019.01.012. Epub 2019 Jan 8.
The aim of this study was to determine the potential toxicity risk of an oxyclozanide suspension to the target animal, bovine. In this experiment, 32 Simmental beef cattle were fattened and fed a full-price diet without antimicrobial agents. The test cattle were divided into 4 groups, which were treated with 0, 1, 3, and 5 times the recommended dosage through continuous intermittent oral administration at intervals of 2 days. The body weight of the cattle was recorded before and after the experiment, and the weight changes were calculated. The safety of the drugs was evaluated by weight gain, observation of clinical toxicity, haematology, clinical chemistry and histopathology. The results showed that the cattle had different degrees of diarrhoea, loss of appetite and depression after administration. The results of clinicopathology had no significant effect. The results of pathological examination showed that there was a certain degree of damage in the 5 times recommended dose group. The recommended dose was safe to use. Thus, the recommended dose should be given by a single oral administration to ensure the safe use of this drug in the clinic.
本研究旨在确定奥硝唑混悬液对靶动物牛的潜在毒性风险。在本实验中，32 头西门塔尔肉牛育肥并饲喂全价日粮，不添加抗菌药物。试验牛分为 4 组，通过连续 2 天间隔的间歇口服，以推荐剂量的 0、1、3 和 5 倍进行连续处理。实验前后记录牛的体重，并计算体重变化。通过体重增加、临床毒性观察、血液学、临床化学和组织病理学来评估药物的安全性。结果表明，给药后牛出现不同程度的腹泻、食欲不振和抑郁。临床病理学结果无显著影响。病理检查结果表明，在 5 倍推荐剂量组有一定程度的损伤。推荐剂量使用安全。因此，建议单次口服给药，以确保该药物在临床上的安全使用。
