Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Orthopaedics, Clinical Epidemiology Unit, Lund, Sweden; Diakonhjemmet Hospital, Department of Rheumatology, National Advisory Unit on Rehabilitation in Rheumatology, Oslo, Norway.
Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Orthopaedics, Clinical Epidemiology Unit, Lund, Sweden.
Osteoarthritis Cartilage. 2019 Apr;27(4):586-592. doi: 10.1016/j.joca.2018.12.018. Epub 2019 Jan 8.
(1) To estimate the life-time genetic contribution for knee osteoarthritis (OA) surgery and (2) to explore any differences in the genetic contribution across age, sex and body mass index (BMI).
We studied the sex-specific genetic contribution to knee OA surgery in a prospective cohort study of 62,490 twins aged 35 years or older with a follow-up period of up to 47 years (10,092 identical and 21,153 non-identical twin pairs, 54% women). To study interactions with age, we graphed the heritabilities over the lifespan for men and women. We also studied the sex-specific heritability across strata of the median BMI to explore any interactions with BMI.
The overall heritability of knee OA surgery was 0.53 (95% confidence intervals [CI] = 0.31-0.75), with higher heritability among women (H = 0.80 (95% CI = 0.73-0.87)) than men (H = 0.39 (95% CI = 0.10-0.69)). For men, the heritability started to rise after age 68. The genetic contribution was particularly low in men above median BMI (H = 0.08, 95% CI = -0.32-0.48). For women, the heritability was consistently high from age 50 to death, independently of BMI (H = 0.77, 95% CI = 0.66-0.87).
There is a higher and more consistent genetic contribution for knee OA surgery in women than men. In men the genetic contribution was relatively low and varied with age and BMI.
（1）估计膝关节骨关节炎（OA）手术的终生遗传贡献，（2）探讨遗传贡献在年龄、性别和体重指数（BMI）方面的差异。
我们对 62490 名年龄在 35 岁及以上的双胞胎进行了一项前瞻性队列研究，随访时间长达 47 年（10092 对同卵双胞胎和 21153 对非同卵双胞胎，女性占 54%），研究了膝关节 OA 手术的性别特异性遗传贡献。为了研究与年龄的相互作用，我们绘制了男女一生中遗传力的变化图。我们还研究了 BMI 中位数各层之间的性别特异性遗传力，以探讨与 BMI 的任何相互作用。
膝关节 OA 手术的总体遗传率为 0.53（95%置信区间[CI]：0.31-0.75），女性的遗传率较高（H=0.80（95%CI：0.73-0.87）），男性的遗传率较低（H=0.39（95%CI：0.10-0.69））。对于男性，遗传率在 68 岁后开始上升。对于 BMI 中位数以上的男性，遗传贡献特别低（H=0.08，95%CI：-0.32-0.48）。对于女性，遗传率从 50 岁到死亡一直保持较高水平，与 BMI 无关（H=0.77，95%CI：0.66-0.87）。
女性膝关节 OA 手术的遗传贡献高于男性，且更一致。在男性中，遗传贡献相对较低，且随年龄和 BMI 而变化。
